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Mutations with Epigenetic Effects in Myeloproliferative Neoplasms and Recent Progress in Treatment: Proceedings from the 5th International Post-ASH Symposium

Authors :
Tefferi, A
Abdel-Wahab, O
Cervantes, F
Crispino, J D
Finazzi, G
Girodon, F
Gisslinger, H
Gotlib, J
Kiladjian, J-J
Licht, J D
Odenike, O
Pardanani, A
Silver, R T
Solary, E
Mughal, T
Mullally, Ann
Levine, R L
Source :
Tefferi, A.O., Abdel-Wahab, F. Cervantes, J.D. Crispino, G. Finazzi, F. Girodon, H. Gisslinger, et al. 2011. Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: proceedings from the 5th international post-ash symposium. Blood Cancer Journal 1(3): e7.
Publication Year :
2011
Publisher :
Nature Publishing Group, 2011.

Abstract

Immediately following the 2010 annual American Society of Hematology (ASH) meeting, the 5th International Post-ASH Symposium on Chronic Myelogenous Leukemia and BCR-ABL1-Negative Myeloproliferative Neoplasms (MPNs) took place on 7–8 December 2010 in Orlando, Florida, USA. During this meeting, the most recent advances in laboratory research and clinical practice, including those that were presented at the 2010 ASH meeting, were discussed among recognized authorities in the field. The current paper summarizes the proceedings of this meeting in BCR-ABL1-negative MPN. We provide a detailed overview of new mutations with putative epigenetic effects (TET oncogene family member 2 (TET2), additional sex comb-like 1 (ASXL1), isocitrate dehydrogenase (IDH) and enhancer of zeste homolog 2 (EZH2)) and an update on treatment with Janus kinase (JAK) inhibitors, pomalidomide, everolimus, interferon-α, midostaurin and cladribine. In addition, the new ‘Dynamic International Prognostic Scoring System (DIPSS)-plus' prognostic model for primary myelofibrosis (PMF) and the clinical relevance of distinguishing essential thrombocythemia from prefibrotic PMF are discussed.

Details

Language :
English
ISSN :
20445385
Database :
Digital Access to Scholarship at Harvard (DASH)
Journal :
Tefferi, A.O., Abdel-Wahab, F. Cervantes, J.D. Crispino, G. Finazzi, F. Girodon, H. Gisslinger, et al. 2011. Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: proceedings from the 5th international post-ash symposium. Blood Cancer Journal 1(3): e7.
Publication Type :
Academic Journal
Accession number :
edshld.1.8603493
Document Type :
Journal Article
Full Text :
https://doi.org/10.1038/bcj.2011.4