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Recovery of vestibular function following hair cell destruction by streptomycin
- Source :
- Hearing research. 62(2)
- Publication Year :
- 1992
- Publisher :
- United States: NASA Center for Aerospace Information (CASI), 1992.
-
Abstract
- Can the vestibular periphery of warm-blooded vertebrates recover functionally from severe sensory hair cell loss? Recent findings in birds suggest a mechanism for recovery but in fact no direct functional evidence has been reported. We produced vestibular hair cell lesions using the ototoxic agent streptomycin sulfate (600 mg/kg/day, 8 days, chicks, Gallus domesticus). Compound action potentials of the vestibular nerve were used as a direct measure of peripheral vestibular function. Vestibular thresholds, neural activation latencies and amplitudes were documented. Eight days of drug treatment elevated thresholds significantly (P < 0.001) and eliminated all but remnants of vestibular activity. Virtually complete physiological recovery occurred in all animals studied over a period of 70 days following treatment. Thresholds recovered within two weeks of drug treatment whereas the return of response morphologies including activation latencies and amplitudes required an additional 6-8 weeks.
- Subjects :
- Life Sciences (General)
Subjects
Details
- Language :
- English
- ISSN :
- 03785955
- Volume :
- 62
- Issue :
- 2
- Database :
- NASA Technical Reports
- Journal :
- Hearing research
- Publication Type :
- Report
- Accession number :
- edsnas.20050000600
- Document Type :
- Report
- Full Text :
- https://doi.org/10.1016/0378-5955(92)90184-O