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The effect of in situ freezing on rabbit patellar tendon. A histologic, biochemical, and biomechanical analysis
- Source :
- The American journal of sports medicine. 20(4)
- Publication Year :
- 1992
- Publisher :
- United States: NASA Center for Aerospace Information (CASI), 1992.
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Abstract
- Cell necrosis has been well documented as one of the many changes that occur in autogenous tendon when it is used to reconstruct the anterior cruciate ligament. The purpose of this experiment was to isolate cell necrosis as a variable and study its effect on the patellar tendon. To accomplish this, both knees of 25 New Zealand White rabbits were operated on. In one knee, a 5-mm wide band of patellar tendon was subjected to two rapid freeze-thaw cycles, while the other knee underwent sham surgery. Histologic evaluation showed a zone of necrosis at 2 and 4 weeks with cellular repopulation complete at 8 weeks. patellar tendon cross-sectional area was 0.118 cm2 at 8 weeks for the frozen specimens compared to 0.102 cm2 for the sham-operated controls. This difference was significant at the P = 0.025 level. Mechanical testing at 4 and 8 weeks revealed no significant changes in tendon length, maximum load, or stiffness. The collagen content was also unchanged at both 4 and 8 weeks.
- Subjects :
- Life Sciences (General)
Subjects
Details
- Language :
- English
- ISSN :
- 03635465
- Volume :
- 20
- Issue :
- 4
- Database :
- NASA Technical Reports
- Journal :
- The American journal of sports medicine
- Publication Type :
- Report
- Accession number :
- edsnas.20050000642
- Document Type :
- Report