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Effects of heavy ion to the primary culture of mouse brain cells
- Source :
- Uchu seibutsu kagaku. 18(3)
- Publication Year :
- 2004
- Publisher :
- United States: NASA Center for Aerospace Information (CASI), 2004.
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Abstract
- To investigate effects of low dose heavy particle radiation to CNS system, we adopted mouse neonatal brain cells in culture being exposed to heavy ions by HIMAC at NIRS and NSRL at BNL. The applied dose varied from 0.05 Gy up to 2.0 Gy. The subsequent biological effects were evaluated by an induction of apoptosis and neuron survival focusing on the dependencies of the animal strains, SCID, B6, B6C3F1, C3H, used for brain cell culture, SCID was the most sensitive and C3H the least sensitive to particle radiation as evaluated by 10% apoptotic criterion. The LET dependency was compared with using SCID and B6 cells exposing to different ions (H, C, Ne, Si, Ar, and Fe). Although no detectable LET dependency was observed in the high LET (55-200 keV/micrometers) and low dose (<0.5 Gy) regions. The survivability profiles of the neurons were different in the mouse strains and ions. In this report, a result of memory and learning function to adult mice after whole-body and brain local irradiation at carbon ion and iron ion.
- Subjects :
- Life Sciences (General)
Subjects
Details
- Language :
- English
- ISSN :
- 09149201
- Volume :
- 18
- Issue :
- 3
- Database :
- NASA Technical Reports
- Journal :
- Uchu seibutsu kagaku
- Publication Type :
- Report
- Accession number :
- edsnas.20050219169
- Document Type :
- Report