Alterations of FFA Glucose and Lactate Metabolism in Shock.

The major metabolic alterations during shock have been studied in detail. The importance of the elevated lactate concentration in influencing oxidative metabolism has been emphasized. This change is probably responsible, at least in part, for the alteration in myocardial metabolism found previously during shock. Phospholipid changes have also been studied with special reference to phospholipids and especially to phosphatidylglycerol. The metabolism of phosphatidylglycerol is quite unique during shock and the importance of red blood cells as well as plasma in producing the alterations have been pointed out. More recent investigations point to important hormonal alterations during shock. Some of these have been investigated in detail and especially the role of insulin release by hyperglycemia was found to be altered during shock.