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Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation

Authors :
Gehani, Simmi Suman
Agrawal-Singh, Shuchi
Dietrich, Nikolaj
Christophersen, Nicolaj Strøyer
Helin, Kristian
Hansen, Klaus
Gehani, Simmi Suman
Agrawal-Singh, Shuchi
Dietrich, Nikolaj
Christophersen, Nicolaj Strøyer
Helin, Kristian
Hansen, Klaus
Source :
Gehani , S S , Agrawal-Singh , S , Dietrich , N , Christophersen , N S , Helin , K & Hansen , K 2010 , ' Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation ' , Molecular Cell , vol. 39 , no. 6 , pp. 886-900 .
Publication Year :
2010

Abstract

Udgivelsesdato: 2010-Sep-24<br />Epigenetic regulation of chromatin structure is essential for the expression of genes determining cellular specification and function. The Polycomb repressive complex 2 (PRC2) di- and trimethylates histone H3 on lysine 27 (H3K27me2/me3) to establish repression of specific genes in embryonic stem cells and during differentiation. How the Polycomb group (PcG) target genes are regulated by environmental cues and signaling pathways is quite unexplored. Here, we show that the mitogen- and stress-activated kinases (MSK), through a mechanism that involves promoter recruitment, histone H3K27me3S28 phosphorylation, and displacement of PcG proteins, lead to gene activation. We present evidence that the H3K27me3S28 phosphorylation is functioning in response to stress signaling, mitogenic signaling, and retinoic acid (RA)-induced neuronal differentiation. We propose that MSK-mediated H3K27me3S28 phosphorylation serves as a mechanism to activate a subset of PcG target genes determined by the biological stimuli and thereby modulate the gene expression program determining cell fate.

Details

Database :
OAIster
Journal :
Gehani , S S , Agrawal-Singh , S , Dietrich , N , Christophersen , N S , Helin , K & Hansen , K 2010 , ' Polycomb Group Protein Displacement and Gene Activation through MSK-Dependent H3K27me3S28 Phosphorylation ' , Molecular Cell , vol. 39 , no. 6 , pp. 886-900 .
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn842759148
Document Type :
Electronic Resource