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Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis
- Source :
- Vogel , L K , Saebo , M , Hoyer , H , Kopp , T I , Vogel , U , Godiksen , S , Frenzel , F B , Hamfjord , J , Bowitz-Lothe , I M , Johnson , E , Kure , E H & Andersen , V 2014 , ' Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis ' , PLOS ONE , vol. 9 , no. 8 , e105254 .
- Publication Year :
- 2014
-
Abstract
- Background & Aims: Inflammation is a major risk factor for development of colorectal cancer (CRC). Prostaglandin synthase cyclooxygenase-2 (COX-2) encoded by the PTGS2 gene is the rate limiting enzyme in prostaglandin synthesis and therefore plays a distinct role as regulator of inflammation. Methods: PTGS2 mRNA levels were determined in intestinal tissues from 85 intestinal adenoma cases, 115 CRC cases, and 17 healthy controls. The functional PTGS2 polymorphisms A-1195G (rs689466), G-765C (rs20417), T8473C (rs5275) were assessed in 200 CRC cases, 991 adenoma cases and 399 controls from the Norwegian KAM cohort. Results: PTGS2 mRNA levels were higher in mild/moderate adenoma tissue compared to morphologically normal tissue from the same individual (P
Details
- Database :
- OAIster
- Journal :
- Vogel , L K , Saebo , M , Hoyer , H , Kopp , T I , Vogel , U , Godiksen , S , Frenzel , F B , Hamfjord , J , Bowitz-Lothe , I M , Johnson , E , Kure , E H & Andersen , V 2014 , ' Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis ' , PLOS ONE , vol. 9 , no. 8 , e105254 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn893889441
- Document Type :
- Electronic Resource