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In vitro and in vivo evaluation of C-20- and C-23-modified derivatives of tylosin against veterinary pathogens.
- Source :
- Journal of antibiotics, 41 (7
- Publication Year :
- 1988
-
Abstract
- Three series of semi-synthetic derivatives of tylosin-related macrolides were evaluated for utility in veterinary medicine. 23-Modified derivatives of 5-O-mycaminosyltylonolide (OMT) possessed potent activity in vitro against species of Pasteurella and Mycoplasma. An experimental infection in chicks caused by Pasteurella multocida was utilized to evaluate efficacy; several of these derivatives of OMT effectively treated the infection when given subcutaneously, but none were effective after oral administration in drinking water. Macrolides retaining the 4'-O-mycarosyl moiety (tylosin, DMT) had relatively poor activity against Pasteurella in vitro. Certain 20-modified derivatives of desmycosin demonstrated good oral bioavailability in chicks and a lead compound with oral efficacy in the Pasteurella infection model was discovered.<br />info:eu-repo/semantics/published
Details
- Database :
- OAIster
- Journal :
- Journal of antibiotics, 41 (7
- Notes :
- No full-text files, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn908366908
- Document Type :
- Electronic Resource