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Structure-activity studies of 20-deoxo-20-amino derivatives of tylosin-related macrolides.
- Source :
- Journal of antibiotics, 42 (11
- Publication Year :
- 1989
-
Abstract
- Reductive amination of the C-20 aldehyde group of tylosin and related macrolides yielded a large series of derivatives with potentially useful antibiotic properties. Evaluation of these new compounds was conducted on the basis of: 1) Broad antimicrobial spectrum in vitro, with particular emphasis on inhibition of Pasteurella multocida and Pasteurella haemolytica; 2) in vivo efficacy, especially when given orally, against P. multocida in experimental infections in chicks; and 3) bioavailability after oral administration to laboratory animals. The most useful activity was found within a series of derivatives produced by reductive amination of desmycosin with secondary amines.<br />info:eu-repo/semantics/published
Details
- Database :
- OAIster
- Journal :
- Journal of antibiotics, 42 (11
- Notes :
- No full-text files, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn908367011
- Document Type :
- Electronic Resource