抗がん剤投与後の味覚変化と血清亜鉛値との関連 <原著論文>

化学療法の有害事象のうち味覚障害は発生頻度の高い有害事象である.味覚と血清亜鉛値との関連については以前から指摘されているが,抗がん剤投与後の味覚変化に血清亜鉛値が影響していることを示した報告は少ない.本研究の目的は,抗がん剤投与後のがん患者の味覚閾値と血清亜鉛値を測定し,両者の関連性を検証することである.60名のがん患者の抗がん剤投与前,抗がん剤投与後3日と投与後6日に味覚と血清亜鉛値,血清銅値を測定した. 抗がん剤投与後の味覚の変化は,塩味で時間経過による有意差を認めた(p<0.01).血清亜鉛値でも時間経過による有意差を認めた(p<0.01).味覚と血清亜鉛値との関係では,抗がん剤投与後3日において,血清亜鉛値と塩味の感度に負の相関を認め(r =- 0.402,p<0.01),血清亜鉛値が低い時,塩味の感度が鈍麻したことが示された.一方,血清銅値と味覚感度には相関を認めなかった.抗がん剤投与後の味覚感度,特に塩味の鈍麻については血清亜鉛値との関連が示された.
Taste disorder is one of the most frequent side effects of chemotherapy. A relationship between serum zinc level and taste sensitivity has been pointed out in previous reports, but there have only been a few reports showing the effect of serum zinc level on taste sensitivity after anticancer drug administration. The purpose of this study was to examine the serum zinc levels and taste thresholds of cancer patients treated with anticancer drugs and to determine whether they are related. Taste thresholds and levels of serum trace elements (zinc and copper) were measured in 60 cancer patients before administration of anticancer drugs and on the three and six days after administration. There were significant differences in the salt threshold with elapse of time after chemotherapy (p<0.01). There were also significant differences in the serum zinc level with elapse of time after chemotherapy (p<0.01). There was a significant relationship between low salt sensitivity and change in serum zinc value (r = -0.402, p<0.01). Although there was no significant relationship between serum copper value and taste sensitivity, there was a relationship between salt sensitivity and serum zinc value.