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Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

Authors :
Wilk, J.B. (Jemma)
Shrine, N.R.G. (Nick)
Loehr, L.R. (Laura)
Zhao, J.H. (Jing Hua)
Manichaikul, A. (Ani)
Lopez, L.M. (Lorna)
Smith, A.V. (Davey)
Heckbert, S.R. (Susan)
Smolonska, J. (Joanna)
Tang, W. (Wenbo)
Loth, D.W. (Daan)
Curjuric, I. (Ivan)
Hui, J. (Jennie)
Cho, M.H. (Michael)
Latourelle, J.C. (Jeanne)
Henry, A. (Amanda)
Aldrich, M.C. (Melinda)
Bakke, A.B. (Arnold B.)
Beaty, T.H. (Terri)
Bentley, A.R. (Amy)
Borecki, I.B. (Ingrid)
Brusselle, G.G. (Guy)
Burkart, K.M. (Kristin)
Chen, T.H.
Couper, D.J. (David)
Crapo, R.O. (Robert)
Davies, G. (Gail)
Dupuis, J. (Josée)
Franceschini, N. (Nora)
Gulsvik, A. (Amund)
Hancock, D.B. (Dana)
Harris, T.B. (Tamara)
Hofman, A. (Albert)
Imboden, M. (Medea)
James, A.L. (Alan)
Khaw, K-T. (Kay-Tee)
Lahousse, L. (Lies)
Launer, L.J. (Lenore)
Litonjua, A.A. (Augusto)
Liu, Y. (YongMei)
Lohman, K. (Kurt)
Lomas, D.J. (David John)
Lumley, T. (Thomas)
Marciante, K. (Kristin)
McArdle, W.L. (Wendy)
Meibohm, B. (Bernd)
Morrison, A.C. (Alanna)
Musk, A.W. (Arthur)
Myers, R.H. (Richard)
North, K.E. (Kari)
Postma, D.S. (Dirkje)
Psaty, B.M. (Bruce)
Rich, S.S. (Stephen)
Rivadeneira Ramirez, F. (Fernando)
Rochat, T. (Thierry)
Rotter, J.I. (Jerome)
Soler Artigas, M. (Maria)
Starr, J.M. (John)
Uitterlinden, A.G. (André)
Wareham, N.J. (Nick)
Wijmenga, C. (Cisca)
Zanen, P. (Pieter)
Province, M.A. (Mike)
Silverman, E. (Edwin)
Deary, I.J. (Ian)
Palmer, C. (Cameron)
Cassano, P.A. (Patricia)
Gudnason, V. (Vilmundur)
Barr, R.G. (Graham)
Loos, R.J.F. (Ruth)
Strachan, D.P. (David)
London, S.J. (Stephanie)
Boezen, H.M. (Marike)
Probst-Hensch, N. (Nicole)
Gharib, S.A. (Sina)
Hall, I.P. (Ian)
O'Connor, G.T. (George)
Tobin, M.D. (Martin)
Stricker, B.H.Ch. (Bruno)
Wilk, J.B. (Jemma)
Shrine, N.R.G. (Nick)
Loehr, L.R. (Laura)
Zhao, J.H. (Jing Hua)
Manichaikul, A. (Ani)
Lopez, L.M. (Lorna)
Smith, A.V. (Davey)
Heckbert, S.R. (Susan)
Smolonska, J. (Joanna)
Tang, W. (Wenbo)
Loth, D.W. (Daan)
Curjuric, I. (Ivan)
Hui, J. (Jennie)
Cho, M.H. (Michael)
Latourelle, J.C. (Jeanne)
Henry, A. (Amanda)
Aldrich, M.C. (Melinda)
Bakke, A.B. (Arnold B.)
Beaty, T.H. (Terri)
Bentley, A.R. (Amy)
Borecki, I.B. (Ingrid)
Brusselle, G.G. (Guy)
Burkart, K.M. (Kristin)
Chen, T.H.
Couper, D.J. (David)
Crapo, R.O. (Robert)
Davies, G. (Gail)
Dupuis, J. (Josée)
Franceschini, N. (Nora)
Gulsvik, A. (Amund)
Hancock, D.B. (Dana)
Harris, T.B. (Tamara)
Hofman, A. (Albert)
Imboden, M. (Medea)
James, A.L. (Alan)
Khaw, K-T. (Kay-Tee)
Lahousse, L. (Lies)
Launer, L.J. (Lenore)
Litonjua, A.A. (Augusto)
Liu, Y. (YongMei)
Lohman, K. (Kurt)
Lomas, D.J. (David John)
Lumley, T. (Thomas)
Marciante, K. (Kristin)
McArdle, W.L. (Wendy)
Meibohm, B. (Bernd)
Morrison, A.C. (Alanna)
Musk, A.W. (Arthur)
Myers, R.H. (Richard)
North, K.E. (Kari)
Postma, D.S. (Dirkje)
Psaty, B.M. (Bruce)
Rich, S.S. (Stephen)
Rivadeneira Ramirez, F. (Fernando)
Rochat, T. (Thierry)
Rotter, J.I. (Jerome)
Soler Artigas, M. (Maria)
Starr, J.M. (John)
Uitterlinden, A.G. (André)
Wareham, N.J. (Nick)
Wijmenga, C. (Cisca)
Zanen, P. (Pieter)
Province, M.A. (Mike)
Silverman, E. (Edwin)
Deary, I.J. (Ian)
Palmer, C. (Cameron)
Cassano, P.A. (Patricia)
Gudnason, V. (Vilmundur)
Barr, R.G. (Graham)
Loos, R.J.F. (Ruth)
Strachan, D.P. (David)
London, S.J. (Stephanie)
Boezen, H.M. (Marike)
Probst-Hensch, N. (Nicole)
Gharib, S.A. (Sina)
Hall, I.P. (Ian)
O'Connor, G.T. (George)
Tobin, M.D. (Martin)
Stricker, B.H.Ch. (Bruno)
Publication Year :
2012

Abstract

Rationale: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. Objectives: Perform meta-analyses of GWAS for airflow obstruction, a key pathophysiologic characteristic ofCOPD assessedby spirometry, in population-based cohorts examining all participants, ever smokers, never smokers, asthma-free participants, and more severe cases. Methods: Fif

Details

Database :
OAIster
Notes :
American Journal of Respiratory and Critical Care Medicine vol. 186 no. 7, pp. 622-632, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn929961890
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1164.rccm.201202-0366OC
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