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Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
- Publication Year :
- 2010
-
Abstract
- Spirometric measures of lung function are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important lung-function measures: forced expiratory volume in the first second (FEV1) and its ratio to forced vital capacity (FEV1/FVC), an indicator of airflow obstruction. This meta-analysis included 20,890 participants of European ancestry from four CHARGE Consortium studies: Atherosclerosis Risk in Communities, Cardiovascular Health Study, Framingham Heart Study and Rotterdam Study. We identified eight loci associated with FEV 1 /FVC (HHIP, GPR126, ADAM19, AGER-PPT2, FAM13A, PTCH1, PID1 and HTR4) and one locus associated with FEV1(INTS12-GSTCD-NPNT) at or near genome-wide significance (P 5 × 10-8) in the CHARGE Consortium dataset. Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease.
Details
- Database :
- OAIster
- Notes :
- Nature Genetics vol. 42 no. 1, pp. 45-52, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn929962179
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.1038.ng.500