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Association of Forced Vital Capacity with the Developmental Gene NCOR2

Authors :
Minelli, C. (Cosetta)
Dean, C.H. (Charlotte H.)
Hind, M. (Matthew)
Alves, A.C. (Alexessander Couto)
Amaral, A.F.S. (André)
Siroux, V. (V.)
Huikari, V. (Ville)
Artigas, M.S.
Evans, D.M. (David M.)
Loth, D.W. (Daan)
Bossé, Y. (Yohan)
Postma, D.S. (Dirkje)
Sin, D.D.
Thompson, J.R. (John)
Demenais, F. (Florence)
Henderson, J. (John)
Bouzigon, E. (Emmanuelle)
Jarvis, D.L. (Deborah)
Jarvelin, M.-R. (Marjo-Riitta)
Burney, P.G.
Gharib, S.A. (Sina)
Wain, L.V. (Louise)
Franceschini, N. (Nora)
Koch, B. (Beate)
Pottinger, T.D. (Tess)
Smith, A.V. (Albert)
Duan, Q. (Qing)
Oldmeadow, C. (Christopher)
Lee, M.K. (Mi Kyeong)
Strachan, D.P. (David P.)
James, A.L. (Alan L.)
Huffman, J.E. (Jennifer)
Vitart, V. (Veronique)
Ramasamy, A. (Adaikalavan)
Wareham, N.J. (Nicholas J.)
Kaprio, J. (Jaakko)
Wang, X.-Q. (Xin-Qun)
Trochet, H. (Holly)
Kähönen, M. (Mika)
Flexeder, C. (Claudia)
Albrecht, E. (Eva)
Lopez, L.M. (Lorna M.)
Jong, K. (Kim) de
Thyagarajan, B. (Bharat)
Enroth, S. (Stefan)
Omenaas, E. (Ernst)
Joshi, P.K. (Peter)
Fall, M. (Magnus)
Viñuela, A. (Ana)
Launer, L.J. (Lenore)
Loehr, L.R. (Laura)
Fornage, M. (Myriam)
Li, G. (Guo)
Wilk, J.B. (Jemma)
Tang, W. (Wenbo)
Manichaikul, A. (Ani)
Lahousse, L. (Lies)
Harris, T.B. (Tamara)
North, K.E. (Kari E.)
Rudnicka, A.R. (Alicja)
Hui, J. (Jennie)
Gu, X. (Xiangjun)
Lumley, T. (Thomas)
Wright, A.F. (Alan F.)
Hastie, N. (Nick)
Campbell, S. (Susan)
Kumar, R. (Rajesh)
Pin, I. (Isabelle)
Scott, R.A. (Robert)
Pietilainen, K.H. (Kirsi Hannele)
Surakka, I. (Ida)
Liu, Y. (YongMei)
Holliday, E.G. (Elizabeth)
Schulz, H. (Holger)
Heinrich, J. (Joachim)
Davies, G. (Gail)
MVonk, J. (Judith)
Wojczynski, M.K. (Mary )
Pouta, A. (Anneli)
Johansson, A. (Åsa)
Wild, S. (Sarah)
Ingelsson, E. (Erik)
Rivadeneira Ramirez, F. (Fernando)
Völzke, H. (Henry)
Hysi, P.G. (Pirro)
Eiriksdottir, G. (Gudny)
Morrison, A.C. (Alanna)
Rotter, J.I. (Jerome I.)
Gao, W. (Wei)
White, W.B. (Wendy)
Rich, S.S. (Stephen S.)
Hofman, A. (Albert)
Aspelund, T. (Thor)
Couper, D.J. (David)
Smith, L.J. (Lewis J.)
Psaty, B.M. (Bruce)
Lohman, K. (Kurt)
Burchard, E.G. (Esteban)
Uitterlinden, A.G. (André)
Garcia, M. (Melissa)
Joubert, B.R. (Bonnie)
McArdle, W.L. (Wendy)
Musk, A.B. (A Bill)
Hansel, C.R.W. (Christian)
Heckbert, S.R. (Susan)
Zgaga, L. (Lina)
Meurs, J.B.J. (Joyce) van
Navarro, P. (Pau)
Rudan, I. (Igor)
Oh, Y.-M. (Yeon-Mok)
Redline, S. (Susan)
Jarvis, D.L. (Deborah L.)
Zhao, J.H. (Jing Hua)
Rantanen, T. (Taina)
Connor, G.T. (George) O'
Ripatti, S. (Samuli)
Scott, R.J. (Rodney)
Karrasch, S. (Stefan)
Grallert, H. (Harald)
Gaddis, N.C. (Nathan C.)
MStarr, J. (John)
Wijmenga, C. (Cisca)
Minster, R.L. (Ryan)
Lederer, C.W. (Carsten)
Pekkanen, J. (Juha)
Gyllensten, U. (Ulf)
Campbell, H. (Harry)
Morris, A.P. (Andrew)
Gläser, S. (Sven)
Hammond, C.J. (Christopher J.)
MBurkart, K. (Kristin)
Beilby, J. (John)
Kritchevsky, S.B. (Stephen B.)
Gudnason, V. (Vilmundur)
Hancock, D.B. (Dana)
Williams, O. (O'Dale)
Polasek, O. (Ozren)
Zemunik, T. (Tatijana)
Kolcic, I. (Ivana)
Petrini, M.F. (Marcy)
Wjst, M. (Matthias)
Kim, W.J. (Woo Jin)
Porteous, D.J. (David J.)
Scotland, G. (Generation)
Smith, B.H. (Blair)
Viljanen, A. (Anne)
Heliovaara, M. (Markku)
Attia, J. (John)
Sayers, I. (Ian)
Hampel, R. (Regina)
Gieger, C. (Christian)
Deary, I.J. (Ian)
Boezen, H.M. (Marike)
Newman, A.B. (Anne B.)
Wilson, J.F. (James F)
Lind, L. (Lars)
Stricker, B.H.Ch. (Bruno)
Teumer, A. (Alexander)
Spector, T.D. (Timothy)
Melén, E. (Erik)
Peters, M.J. (Marjolein)
Lange, L.A. (Leslie)
Barr, R.G. (Graham)
Bracke, K.R. (Ken)
MVerhamme, F. (Fien)
Sung, J. (Joohon)
Hiemstra, P.S. (Pieter)
Cassano, P.A. (Patricia)
Sood, A. (Akshay)
Hayward, C. (Caroline)
Dupuis, J. (Josée)
Hall, I.P. (Ian)
Brusselle, G.G. (Guy)
Tobin, M.D. (Martin)
London, S.J. (Stephanie J)
Minelli, C. (Cosetta)
Dean, C.H. (Charlotte H.)
Hind, M. (Matthew)
Alves, A.C. (Alexessander Couto)
Amaral, A.F.S. (André)
Siroux, V. (V.)
Huikari, V. (Ville)
Artigas, M.S.
Evans, D.M. (David M.)
Loth, D.W. (Daan)
Bossé, Y. (Yohan)
Postma, D.S. (Dirkje)
Sin, D.D.
Thompson, J.R. (John)
Demenais, F. (Florence)
Henderson, J. (John)
Bouzigon, E. (Emmanuelle)
Jarvis, D.L. (Deborah)
Jarvelin, M.-R. (Marjo-Riitta)
Burney, P.G.
Gharib, S.A. (Sina)
Wain, L.V. (Louise)
Franceschini, N. (Nora)
Koch, B. (Beate)
Pottinger, T.D. (Tess)
Smith, A.V. (Albert)
Duan, Q. (Qing)
Oldmeadow, C. (Christopher)
Lee, M.K. (Mi Kyeong)
Strachan, D.P. (David P.)
James, A.L. (Alan L.)
Huffman, J.E. (Jennifer)
Vitart, V. (Veronique)
Ramasamy, A. (Adaikalavan)
Wareham, N.J. (Nicholas J.)
Kaprio, J. (Jaakko)
Wang, X.-Q. (Xin-Qun)
Trochet, H. (Holly)
Kähönen, M. (Mika)
Flexeder, C. (Claudia)
Albrecht, E. (Eva)
Lopez, L.M. (Lorna M.)
Jong, K. (Kim) de
Thyagarajan, B. (Bharat)
Enroth, S. (Stefan)
Omenaas, E. (Ernst)
Joshi, P.K. (Peter)
Fall, M. (Magnus)
Viñuela, A. (Ana)
Launer, L.J. (Lenore)
Loehr, L.R. (Laura)
Fornage, M. (Myriam)
Li, G. (Guo)
Wilk, J.B. (Jemma)
Tang, W. (Wenbo)
Manichaikul, A. (Ani)
Lahousse, L. (Lies)
Harris, T.B. (Tamara)
North, K.E. (Kari E.)
Rudnicka, A.R. (Alicja)
Hui, J. (Jennie)
Gu, X. (Xiangjun)
Lumley, T. (Thomas)
Wright, A.F. (Alan F.)
Hastie, N. (Nick)
Campbell, S. (Susan)
Kumar, R. (Rajesh)
Pin, I. (Isabelle)
Scott, R.A. (Robert)
Pietilainen, K.H. (Kirsi Hannele)
Surakka, I. (Ida)
Liu, Y. (YongMei)
Holliday, E.G. (Elizabeth)
Schulz, H. (Holger)
Heinrich, J. (Joachim)
Davies, G. (Gail)
MVonk, J. (Judith)
Wojczynski, M.K. (Mary )
Pouta, A. (Anneli)
Johansson, A. (Åsa)
Wild, S. (Sarah)
Ingelsson, E. (Erik)
Rivadeneira Ramirez, F. (Fernando)
Völzke, H. (Henry)
Hysi, P.G. (Pirro)
Eiriksdottir, G. (Gudny)
Morrison, A.C. (Alanna)
Rotter, J.I. (Jerome I.)
Gao, W. (Wei)
White, W.B. (Wendy)
Rich, S.S. (Stephen S.)
Hofman, A. (Albert)
Aspelund, T. (Thor)
Couper, D.J. (David)
Smith, L.J. (Lewis J.)
Psaty, B.M. (Bruce)
Lohman, K. (Kurt)
Burchard, E.G. (Esteban)
Uitterlinden, A.G. (André)
Garcia, M. (Melissa)
Joubert, B.R. (Bonnie)
McArdle, W.L. (Wendy)
Musk, A.B. (A Bill)
Hansel, C.R.W. (Christian)
Heckbert, S.R. (Susan)
Zgaga, L. (Lina)
Meurs, J.B.J. (Joyce) van
Navarro, P. (Pau)
Rudan, I. (Igor)
Oh, Y.-M. (Yeon-Mok)
Redline, S. (Susan)
Jarvis, D.L. (Deborah L.)
Zhao, J.H. (Jing Hua)
Rantanen, T. (Taina)
Connor, G.T. (George) O'
Ripatti, S. (Samuli)
Scott, R.J. (Rodney)
Karrasch, S. (Stefan)
Grallert, H. (Harald)
Gaddis, N.C. (Nathan C.)
MStarr, J. (John)
Wijmenga, C. (Cisca)
Minster, R.L. (Ryan)
Lederer, C.W. (Carsten)
Pekkanen, J. (Juha)
Gyllensten, U. (Ulf)
Campbell, H. (Harry)
Morris, A.P. (Andrew)
Gläser, S. (Sven)
Hammond, C.J. (Christopher J.)
MBurkart, K. (Kristin)
Beilby, J. (John)
Kritchevsky, S.B. (Stephen B.)
Gudnason, V. (Vilmundur)
Hancock, D.B. (Dana)
Williams, O. (O'Dale)
Polasek, O. (Ozren)
Zemunik, T. (Tatijana)
Kolcic, I. (Ivana)
Petrini, M.F. (Marcy)
Wjst, M. (Matthias)
Kim, W.J. (Woo Jin)
Porteous, D.J. (David J.)
Scotland, G. (Generation)
Smith, B.H. (Blair)
Viljanen, A. (Anne)
Heliovaara, M. (Markku)
Attia, J. (John)
Sayers, I. (Ian)
Hampel, R. (Regina)
Gieger, C. (Christian)
Deary, I.J. (Ian)
Boezen, H.M. (Marike)
Newman, A.B. (Anne B.)
Wilson, J.F. (James F)
Lind, L. (Lars)
Stricker, B.H.Ch. (Bruno)
Teumer, A. (Alexander)
Spector, T.D. (Timothy)
Melén, E. (Erik)
Peters, M.J. (Marjolein)
Lange, L.A. (Leslie)
Barr, R.G. (Graham)
Bracke, K.R. (Ken)
MVerhamme, F. (Fien)
Sung, J. (Joohon)
Hiemstra, P.S. (Pieter)
Cassano, P.A. (Patricia)
Sood, A. (Akshay)
Hayward, C. (Caroline)
Dupuis, J. (Josée)
Hall, I.P. (Ian)
Brusselle, G.G. (Guy)
Tobin, M.D. (Martin)
London, S.J. (Stephanie J)
Publication Year :
2016

Abstract

Background Forced Vital Capacity (FVC) is an important predictor of all-cause mortality in the absence of chronic respiratory conditions. Epidemiological evidence highlights the role of early life factors on adult FVC, pointing to environmental exposures and genes affecting lung development as risk factors for low FVC later in life. Although highly heritable, a small number of genes have been found associated with FVC, and we aimed at identifying further genetic variants by focusing on lung development genes. Methods Per-allele effects of 24,728 SNPs in 403 genes involved in lung development were tested in 7,749 adults from three studies (NFBC1966, ECRHS, EGEA). The most significant SNP for the top 25 genes was followed-up in 46,103 adults (CHARGE and SpiroMeta consortia) and 5,062 chil

Details

Database :
OAIster
Notes :
application/pdf, PLoS ONE vol. 11 no. 2, English
Publication Type :
Electronic Resource
Accession number :
edsoai.ocn957103618
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1371.journal.pone.0147388
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