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Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus
- Source :
- Lawrenson , K , Kar , S , McCue , K , Kuchenbaeker , K , Michailidou , K , Tyrer , J , Beesley , J , Ramus , S J , Li , Q , Delgado , M K , Lee , J M , Aittomäki , K , Andrulis , I L , Anton-Culver , H , Arndt , V , Arun , B K , Arver , B , Bandera , E V , Barile , M , Barkardottir , R B , Barrowdale , D , Beckmann , M W , Benitez , J , Berchuck , A , Bisogna , M , Bjorge , L , Blomqvist , C , Blot , W , Bogdanova , N , Bojesen , A , Bojesen , S E , Bolla , M K , Bonanni , B , Borresen-Dale , A-L , Brauch , H , Brennan , P , Brenner , H , Bruinsma , F , Brunet , J , Buhari , S A , Burwinkel , B , Butzow , R , Buys , S S , Cai , Q , Caldes , T , Campbell , I , Canniotto , R , Chang-Claude , J , Chiquette , J , Choi , J-Y , Claes , K B M , Cook , L S , Cox , A , Cramer , D W , Cross , S S , Cybulski , C , Czene , K , Daly , M B , Damiola , F , Dansonka-Mieszkowska , A , Darabi , H , Dennis , J , Devilee , P , Diez , O , Doherty , J A , Domchek , S M , Dorfling , C M , Doerk , T , Dumont , M , Ehrencrona , H , Ejlertsen , B , Ellis , S , Engel , C , Lee , E , Evans , D G , Fasching , P A , Feliubadalo , L , Figueroa , J , Flesch-Janys , D , Fletcher , O , Flyger , H , Foretova , L , Fostira , F , Foulkes , W D , Fridley , B L , Friedman , E , Frost , D , Gambino , G , Ganz , P A , Garber , J , Garcia-Closas , M , Gentry-Maharaj , A , Ghoussaini , M , Giles , G G , Glasspool , R , Godwin , A K , Goldberg , M S , Goldgar , D E , Gonzalez-Neira , A , Goode , E L , Goodman , M T , Greene , M H , Gronwald , J , Guenel , P , Haiman , C A , Hall , P , Hallberg , E , Hamann , U , Hansen , T V O , Harrington , P A , Hartman , M , Hassan , N , Healey , S , Heitz , F , Herzog , J , Hogdall , E , Hogdall , C K , Hogervorst , F B L , Hollestelle , A , Hopper , J L , Hulick , P J , Huzarski , T , Imyanitov , E N , Isaacs , C , Ito , H , Jakubowska , A , Janavicius , R , Jensen , A , John , E M , Johnson , N , Kabisch , M , Kang , D , Kapuscinski , M , Karlan , B Y , Khan , S , Kieme
- Publication Year :
- 2016
-
Abstract
- A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P = 9.2 x 10(-20)), ER-negative BC (P = 1.1 x 10(-13)), BRCA1-associated BC (P = 7.7 x 10(-16)) and triple negative BC (P-diff = 2 x 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P = 2 x 10(-3)) and ABHD8 (P
Details
- Database :
- OAIster
- Journal :
- Lawrenson , K , Kar , S , McCue , K , Kuchenbaeker , K , Michailidou , K , Tyrer , J , Beesley , J , Ramus , S J , Li , Q , Delgado , M K , Lee , J M , Aittomäki , K , Andrulis , I L , Anton-Culver , H , Arndt , V , Arun , B K , Arver , B , Bandera , E V , Barile , M , Barkardottir , R B , Barrowdale , D , Beckmann , M W , Benitez , J , Berchuck , A , Bisogna , M , Bjorge , L , Blomqvist , C , Blot , W , Bogdanova , N , Bojesen , A , Bojesen , S E , Bolla , M K , Bonanni , B , Borresen-Dale , A-L , Brauch , H , Brennan , P , Brenner , H , Bruinsma , F , Brunet , J , Buhari , S A , Burwinkel , B , Butzow , R , Buys , S S , Cai , Q , Caldes , T , Campbell , I , Canniotto , R , Chang-Claude , J , Chiquette , J , Choi , J-Y , Claes , K B M , Cook , L S , Cox , A , Cramer , D W , Cross , S S , Cybulski , C , Czene , K , Daly , M B , Damiola , F , Dansonka-Mieszkowska , A , Darabi , H , Dennis , J , Devilee , P , Diez , O , Doherty , J A , Domchek , S M , Dorfling , C M , Doerk , T , Dumont , M , Ehrencrona , H , Ejlertsen , B , Ellis , S , Engel , C , Lee , E , Evans , D G , Fasching , P A , Feliubadalo , L , Figueroa , J , Flesch-Janys , D , Fletcher , O , Flyger , H , Foretova , L , Fostira , F , Foulkes , W D , Fridley , B L , Friedman , E , Frost , D , Gambino , G , Ganz , P A , Garber , J , Garcia-Closas , M , Gentry-Maharaj , A , Ghoussaini , M , Giles , G G , Glasspool , R , Godwin , A K , Goldberg , M S , Goldgar , D E , Gonzalez-Neira , A , Goode , E L , Goodman , M T , Greene , M H , Gronwald , J , Guenel , P , Haiman , C A , Hall , P , Hallberg , E , Hamann , U , Hansen , T V O , Harrington , P A , Hartman , M , Hassan , N , Healey , S , Heitz , F , Herzog , J , Hogdall , E , Hogdall , C K , Hogervorst , F B L , Hollestelle , A , Hopper , J L , Hulick , P J , Huzarski , T , Imyanitov , E N , Isaacs , C , Ito , H , Jakubowska , A , Janavicius , R , Jensen , A , John , E M , Johnson , N , Kabisch , M , Kang , D , Kapuscinski , M , Karlan , B Y , Khan , S , Kieme
- Notes :
- 22, Lawrenson , K , Kar , S , McCue , K , Kuchenbaeker , K , Michailidou , K , Tyrer , J , Beesley , J , Ramus , S J , Li , Q , Delgado , M K , Lee , J M , Aittomäki , K , Andrulis , I L , Anton-Culver , H , Arndt , V , Arun , B K , Arver , B , Bandera , E V , Barile , M , Barkardottir , R B , Barrowdale , D , Beckmann , M W , Benitez , J , Berchuck , A , Bisogna , M , Bjorge , L , Blomqvist , C , Blot , W , Bogdanova , N , Bojesen , A , Bojesen , S E , Bolla , M K , Bonanni , B , Borresen-Dale , A-L , Brauch , H , Brennan , P , Brenner , H , Bruinsma , F , Brunet , J , Buhari , S A , Burwinkel , B , Butzow , R , Buys , S S , Cai , Q , Caldes , T , Campbell , I , Canniotto , R , Chang-Claude , J , Chiquette , J , Choi , J-Y , Claes , K B M , Cook , L S , Cox , A , Cramer , D W , Cross , S S , Cybulski , C , Czene , K , Daly , M B , Damiola , F , Dansonka-Mieszkowska , A , Darabi , H , Dennis , J , Devilee , P , Diez , O , Doherty , J A , Domchek , S M , Dorfling , C M , Doerk , T , Dumont , M , Ehrencrona , H , Ejlertsen , B , Ellis , S , Engel , C , Lee , E , Evans , D G , Fasching , P A , Feliubadalo , L , Figueroa , J , Flesch-Janys , D , Fletcher , O , Flyger , H , Foretova , L , Fostira , F , Foulkes , W D , Fridley , B L , Friedman , E , Frost , D , Gambino , G , Ganz , P A , Garber , J , Garcia-Closas , M , Gentry-Maharaj , A , Ghoussaini , M , Giles , G G , Glasspool , R , Godwin , A K , Goldberg , M S , Goldgar , D E , Gonzalez-Neira , A , Goode , E L , Goodman , M T , Greene , M H , Gronwald , J , Guenel , P , Haiman , C A , Hall , P , Hallberg , E , Hamann , U , Hansen , T V O , Harrington , P A , Hartman , M , Hassan , N , Healey , S , Heitz , F , Herzog , J , Hogdall , E , Hogdall , C K , Hogervorst , F B L , Hollestelle , A , Hopper , J L , Hulick , P J , Huzarski , T , Imyanitov , E N , Isaacs , C , Ito , H , Jakubowska , A , Janavicius , R , Jensen , A , John , E M , Johnson , N , Kabisch , M , Kang , D , Kapuscinski , M , Karlan , B Y , Khan , S , Kieme, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn965754868
- Document Type :
- Electronic Resource