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Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction
- Source :
- Soderholm , S , Fu , Y , Gaelings , L , Belanov , S , Yetukuri , L , Berlinkov , M , Cheltsov , A V , Anders , S , Aittokallio , T , Nyman , T A , Matikainen , S & Kainov , D E 2016 , ' Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction ' Viruses , vol 8 , no. 10 , 269 . DOI: 10.3390/v8100269
- Publication Year :
- 2016
-
Abstract
- Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV-host interactions, we re-analyzed our recent transcriptomics, metabolomics, proteomics, phosphoproteomics, and genomics/virtual ligand screening data. We identified 713 potential modulators targeting 199 cellular and two viral proteins. Anti-influenza activity for 48 of them has been reported previously, whereas the antiviral efficacy of the 665 remains unknown. Studying anti-influenza efficacy and immuno/neuro-modulating properties of these compounds and their combinations as well as potential viral and host resistance to them may lead to the discovery of novel modulators of IAV-host interactions, which might be more effective than the currently available anti-influenza therapeutics.
Details
- Database :
- OAIster
- Journal :
- Soderholm , S , Fu , Y , Gaelings , L , Belanov , S , Yetukuri , L , Berlinkov , M , Cheltsov , A V , Anders , S , Aittokallio , T , Nyman , T A , Matikainen , S & Kainov , D E 2016 , ' Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction ' Viruses , vol 8 , no. 10 , 269 . DOI: 10.3390/v8100269
- Notes :
- 15, Soderholm , S , Fu , Y , Gaelings , L , Belanov , S , Yetukuri , L , Berlinkov , M , Cheltsov , A V , Anders , S , Aittokallio , T , Nyman , T A , Matikainen , S & Kainov , D E 2016 , ' Multi-Omics Studies towards Novel Modulators of Influenza A Virus-Host Interaction ' Viruses , vol 8 , no. 10 , 269 . DOI: 10.3390/v8100269, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.ocn965754870
- Document Type :
- Electronic Resource