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Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study

Authors :
Johnson, N. (Nichola)
Dudbridge, F. (Frank)
Orr, N. (Nick)
Gibson, L.J. (Lorna)
Jones, M. (Michael)
Schoemaker, M. (Minouk)
Folkerd, E.J. (Elizabeth J.)
Haynes, B.P. (Ben P.)
Hopper, J.L. (John)
Southey, M.C. (Melissa)
Dite, G.S. (Gillian S.)
Apicella, C. (Carmel)
Schmidt, M.K. (Marjanka)
Broeks, A. (Annegien)
Veer, L.J. (Laura) van 't
Atsma, F. (Femke)
Muir, K.R. (K.)
Lophatananon, A. (Artitaya)
Fasching, P.A. (Peter)
Beckmann, M.W. (Matthias)
Ekici, A.B. (Arif)
Renner, S.P. (S.)
Sawyer, E.J. (Elinor)
Tomlinson, I.P. (Ian)
Kerin, M. (Michael)
Miller, N. (Nicola)
Burwinkel, B. (Barbara)
Marme, F. (Frederik)
Schneeweiss, A. (Andreas)
Sohn, C. (Christof)
Guénel, P. (Pascal)
Truong, T. (Thérèse)
Cordina, E. (Emilie)
Menegaux, F. (Florence)
Bojesen, S.E. (Stig)
Nordestgaard, B.G. (Børge)
Flyger, H. (Henrik)
Milne, R.L. (Roger)
Zamora, M.P. (Pilar)
Arias Pérez, J.I. (José Ignacio)
Benítez, J. (Javier)
Bernstein, L. (Leslie)
Anton-Culver, H. (Hoda)
Ziogas, A. (Argyrios)
Clarke Dur, C. (Christina)
Brenner, H. (Hermann)
Müller, H. (Heiko)
Arndt, V. (Volker)
Dieffenbach, A.K. (Aida Karina)
Meindl, A. (Alfons)
Heil, J. (Joerg)
Bartram, C.R. (Claus)
Schmutzler, R.K. (Rita)
Brauch, H. (Hiltrud)
Justenhoven, C. (Christina)
Ko, Y-D. (Yon-Dschun)
Nevanlinna, H. (Heli)
Muranen, T.A. (Taru A.)
Aittomäki, K. (Kristiina)
Blomqvist, C. (Carl)
Matsuo, K. (Keitaro)
Dörk, T. (Thilo)
Bogdanova, N.V. (Natalia)
Antonenkova, N.N. (Natalia N.)
Lindblom, A. (Annika)
Mannermaa, A. (Arto)
Kataja, V. (Vesa)
Kosma, V-M. (Veli-Matti)
Hartikainen, J.M. (J.)
Chenevix-Trench, G. (Georgia)
Beesley, J. (Jonathan)
Wu, A.H. (Anna)
Van Den Berg, D. (David)
Tseng, C.-C. (Chiu-Chen)
Lambrechts, D. (Diether)
Smeets, D. (Dominiek)
Neven, P. (Patrick)
Wildiers, H. (Hans)
Chang-Claude, J. (Jenny)
Rudolph, A. (Anja)
Nickels, S. (Stefan)
Flesch-Janys, D. (Dieter)
Radice, P. (Paolo)
Peterlongo, P. (Paolo)
Bonnani, B. (Bernardo)
Pensotti, V. (Valeria)
Couch, F.J. (Fergus J.)
Olson, J.E. (Janet)
Wang, X. (Xianshu)
Fredericksen, Z. (Zachary)
Pankratz, V.S. (Shane)
Giles, G.G. (Graham G.)
Severi, G. (Gianluca)
Baglietto, L. (Laura)
Haiman, C.A. (Christopher)
Simard, J. (Jacques)
Goldberg, M.S. (Mark)
Labrèche, F. (France)
Dumont, M. (Martine)
Soucy, P. (Penny)
Teo, S.-H. (Soo-Hwang)
Yip, C.H. (Cheng Har)
Phuah, S.-Y. (Sze-Yee)
Cornes, B.K. (Belinda K.)
Kristensen, V.N. (Vessela N.)
Grenaker Alnæs, G. (Grethe)
Borresen-Dale, A.-L. (Anne-Lise)
Zheng, W. (Wei)
Winqvist, R. (Robert)
Pykäs, K. (Katri)
Jukkola-Vuorinen, A. (Arja)
Grip, M. (Mervi)
Andrulis, I.L. (Irene)
Knight, J.A. (Julia)
Glendon, G. (Gord)
Mulligan, A.-M. (Anna-Marie)
Devillee, P. (Peter)
Figueroa, J.D. (Jonine)
Chanock, S.J. (Stephen)
Lissowska, J. (Jolanta)
Sherman, M.E. (Mark)
Hall, P. (Per)
Schoof, N. (Nils)
Hooning, M.J. (Maartje)
Hollestelle, A. (Antoinette)
Oldenburg, R.A. (Rogier)
Tilanus-Linthorst, M.M.A. (Madeleine)
Liu, J. (Jianjun)
Cox, A. (Angela)
Brock, I.W. (Ian)
Reed, M.W.R. (Malcolm)
Cross, S.S. (Simon)
Blot, W.J. (William)
Signorello, L.B. (Lisa B.)
Pharoah, P.D.P. (Paul)
Dunning, A.M. (Alison)
Shah, M. (Mitul)
Kang, D. (Daehee)
Noh, D.-Y. (Dong-Young)
Park, S.K. (Sue K.)
Choi, J.-Y. (Ji-Yeob)
Hartman, M. (Mikael)
Miao, X.
Lim, W.Y. (Wei Yen)
Tang, A. (Anthony)
Hamann, U. (Ute)
Försti, A. (Asta)
Rud̈iger, T. (Thomas)
Ulmer, H.U. (Hans)
Jakubowska, A. (Anna)
Lubinski, J. (Jan)
Jaworska-Bieniek, K. (Katarzyna)
Durda, K. (Katarzyna)
Sangrajrang, S. (Suleeporn)
Gaborieau, V. (Valerie)
Brennan, P. (Paul)
McKay, J. (James)
Slager, S. (Susan)
Toland, A.E. (Amanda E.)
Vachon, C. (Celine)
Yannoukakos, D. (Drakoulis)
Shen, C.-Y. (Chen-Yang)
Yu, J-C. (Jyh-Cherng)
Huang, C.-S. (Chiun-Sheng)
Hou, M.-F. (Ming-Feng)
González-Neira, A. (Anna)
Tessier, D.C. (Daniel C.)
Vincent, D. (Daniel)
Bacot, F. (Francois)
Luccarini, C. (Craig)
Dennis, J. (Joe)
Michailidou, K. (Kyriaki)
Bolla, M.K. (Manjeet K.)
Wang, J. (Jinxia)
Easton, D.F. (Douglas)
García-Closas, M. (Montserrat)
Dowsett, M. (Mitch)
Ashworth, A. (Alan)
Swerdlow, A.J. (Anthony )
Peto, J. (Julian)
Santos Silva, I. (Isabel) dos
Fletcher, O. (Olivia)
Johnson, N. (Nichola)
Dudbridge, F. (Frank)
Orr, N. (Nick)
Gibson, L.J. (Lorna)
Jones, M. (Michael)
Schoemaker, M. (Minouk)
Folkerd, E.J. (Elizabeth J.)
Haynes, B.P. (Ben P.)
Hopper, J.L. (John)
Southey, M.C. (Melissa)
Dite, G.S. (Gillian S.)
Apicella, C. (Carmel)
Schmidt, M.K. (Marjanka)
Broeks, A. (Annegien)
Veer, L.J. (Laura) van 't
Atsma, F. (Femke)
Muir, K.R. (K.)
Lophatananon, A. (Artitaya)
Fasching, P.A. (Peter)
Beckmann, M.W. (Matthias)
Ekici, A.B. (Arif)
Renner, S.P. (S.)
Sawyer, E.J. (Elinor)
Tomlinson, I.P. (Ian)
Kerin, M. (Michael)
Miller, N. (Nicola)
Burwinkel, B. (Barbara)
Marme, F. (Frederik)
Schneeweiss, A. (Andreas)
Sohn, C. (Christof)
Guénel, P. (Pascal)
Truong, T. (Thérèse)
Cordina, E. (Emilie)
Menegaux, F. (Florence)
Bojesen, S.E. (Stig)
Nordestgaard, B.G. (Børge)
Flyger, H. (Henrik)
Milne, R.L. (Roger)
Zamora, M.P. (Pilar)
Arias Pérez, J.I. (José Ignacio)
Benítez, J. (Javier)
Bernstein, L. (Leslie)
Anton-Culver, H. (Hoda)
Ziogas, A. (Argyrios)
Clarke Dur, C. (Christina)
Brenner, H. (Hermann)
Müller, H. (Heiko)
Arndt, V. (Volker)
Dieffenbach, A.K. (Aida Karina)
Meindl, A. (Alfons)
Heil, J. (Joerg)
Bartram, C.R. (Claus)
Schmutzler, R.K. (Rita)
Brauch, H. (Hiltrud)
Justenhoven, C. (Christina)
Ko, Y-D. (Yon-Dschun)
Nevanlinna, H. (Heli)
Muranen, T.A. (Taru A.)
Aittomäki, K. (Kristiina)
Blomqvist, C. (Carl)
Matsuo, K. (Keitaro)
Dörk, T. (Thilo)
Bogdanova, N.V. (Natalia)
Antonenkova, N.N. (Natalia N.)
Lindblom, A. (Annika)
Mannermaa, A. (Arto)
Kataja, V. (Vesa)
Kosma, V-M. (Veli-Matti)
Hartikainen, J.M. (J.)
Chenevix-Trench, G. (Georgia)
Beesley, J. (Jonathan)
Wu, A.H. (Anna)
Van Den Berg, D. (David)
Tseng, C.-C. (Chiu-Chen)
Lambrechts, D. (Diether)
Smeets, D. (Dominiek)
Neven, P. (Patrick)
Wildiers, H. (Hans)
Chang-Claude, J. (Jenny)
Rudolph, A. (Anja)
Nickels, S. (Stefan)
Flesch-Janys, D. (Dieter)
Radice, P. (Paolo)
Peterlongo, P. (Paolo)
Bonnani, B. (Bernardo)
Pensotti, V. (Valeria)
Couch, F.J. (Fergus J.)
Olson, J.E. (Janet)
Wang, X. (Xianshu)
Fredericksen, Z. (Zachary)
Pankratz, V.S. (Shane)
Giles, G.G. (Graham G.)
Severi, G. (Gianluca)
Baglietto, L. (Laura)
Haiman, C.A. (Christopher)
Simard, J. (Jacques)
Goldberg, M.S. (Mark)
Labrèche, F. (France)
Dumont, M. (Martine)
Soucy, P. (Penny)
Teo, S.-H. (Soo-Hwang)
Yip, C.H. (Cheng Har)
Phuah, S.-Y. (Sze-Yee)
Cornes, B.K. (Belinda K.)
Kristensen, V.N. (Vessela N.)
Grenaker Alnæs, G. (Grethe)
Borresen-Dale, A.-L. (Anne-Lise)
Zheng, W. (Wei)
Winqvist, R. (Robert)
Pykäs, K. (Katri)
Jukkola-Vuorinen, A. (Arja)
Grip, M. (Mervi)
Andrulis, I.L. (Irene)
Knight, J.A. (Julia)
Glendon, G. (Gord)
Mulligan, A.-M. (Anna-Marie)
Devillee, P. (Peter)
Figueroa, J.D. (Jonine)
Chanock, S.J. (Stephen)
Lissowska, J. (Jolanta)
Sherman, M.E. (Mark)
Hall, P. (Per)
Schoof, N. (Nils)
Hooning, M.J. (Maartje)
Hollestelle, A. (Antoinette)
Oldenburg, R.A. (Rogier)
Tilanus-Linthorst, M.M.A. (Madeleine)
Liu, J. (Jianjun)
Cox, A. (Angela)
Brock, I.W. (Ian)
Reed, M.W.R. (Malcolm)
Cross, S.S. (Simon)
Blot, W.J. (William)
Signorello, L.B. (Lisa B.)
Pharoah, P.D.P. (Paul)
Dunning, A.M. (Alison)
Shah, M. (Mitul)
Kang, D. (Daehee)
Noh, D.-Y. (Dong-Young)
Park, S.K. (Sue K.)
Choi, J.-Y. (Ji-Yeob)
Hartman, M. (Mikael)
Miao, X.
Lim, W.Y. (Wei Yen)
Tang, A. (Anthony)
Hamann, U. (Ute)
Försti, A. (Asta)
Rud̈iger, T. (Thomas)
Ulmer, H.U. (Hans)
Jakubowska, A. (Anna)
Lubinski, J. (Jan)
Jaworska-Bieniek, K. (Katarzyna)
Durda, K. (Katarzyna)
Sangrajrang, S. (Suleeporn)
Gaborieau, V. (Valerie)
Brennan, P. (Paul)
McKay, J. (James)
Slager, S. (Susan)
Toland, A.E. (Amanda E.)
Vachon, C. (Celine)
Yannoukakos, D. (Drakoulis)
Shen, C.-Y. (Chen-Yang)
Yu, J-C. (Jyh-Cherng)
Huang, C.-S. (Chiun-Sheng)
Hou, M.-F. (Ming-Feng)
González-Neira, A. (Anna)
Tessier, D.C. (Daniel C.)
Vincent, D. (Daniel)
Bacot, F. (Francois)
Luccarini, C. (Craig)
Dennis, J. (Joe)
Michailidou, K. (Kyriaki)
Bolla, M.K. (Manjeet K.)
Wang, J. (Jinxia)
Easton, D.F. (Douglas)
García-Closas, M. (Montserrat)
Dowsett, M. (Mitch)
Ashworth, A. (Alan)
Swerdlow, A.J. (Anthony )
Peto, J. (Julian)
Santos Silva, I. (Isabel) dos
Fletcher, O. (Olivia)
Publication Year :
2014

Abstract

INTRODUCTION: We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.METHODS: We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.RESULTS: We confirmed the association of rs10235235 with breast

Details

Database :
OAIster
Notes :
application/pdf, Breast Cancer Research (Print) vol. 16 no. 3, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1019677324
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1186.bcr3662
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