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Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis
Authors :
Rooij, F.J.A. (Frank) van Qayyum, Q. (Rehan) Smith, A.V. (Albert Vernon) Zhou, Y. (Yi) Trompet, S. (Stella) Tanaka, T. (Toshiko) Keller, M.F. (Margaux) Chang, L.-C. (Li-Ching) Schmidt, H. (Helena) Yang, M.-L. (Min-Lee) Chen, M.-H. (Ming-Huei) Hayes, J. (James) Johnson, A.D. (Andrew) Yanek, L.R. (Lisa) Mueller, C. (Christian) Lange, L.A. (Leslie) Floyd, J. (James) Ghanbari, M. (Mohsen) Zonderman, A.B. Jukema, J.W. Hofman, A. (Albert) Duijn, C.M. (Cornelia) van Desch, K.C. (Karl C.) Saba, Y. (Yasaman) Ozel, A.B. (Ayse) Snively, B.M. (Beverly M.) Wu, J.-Y. (Jer-Yuarn) Schmidt, R. (Reinhold) Fornage, M. (Myriam) Klein, R.J. (Robert J.) Fox, C.S. (Caroline) Matsuda, K. (Koichi) Kamatani, N. (Naoyuki) Wild, P.S. (Philipp S.) Stott, D.J. (David J.) Ford, I. Slagboom, P.E. (Eline) Yang, J. (Jaden) Chu, A.Y. (Audrey Y) Lambert, A.J. (Amy J.) Uitterlinden, A.G. (André) Franco, O.H. (Oscar) Hofer, E. (Edith) Ginsburg, D. (David) Hu, B. (Bella) Keating, J. (John) Schick, U.M. (Ursula) Brody, J.A. (Jennifer A.) Li, J.Z. (Jun Z.) Chen, Z. (Zhao) Zeller, T. (Tanja) Guralnik, J.M. (Jack M.) Chasman, D.I. (Daniel) Peters, L.L. (Luanne L.) Kubo, M. (Michiaki) Becker, D.M. (Diane M.) Li, J. (Jin) Eiriksdottir, G. (Gudny) Rotter, J.I. (Jerome I.) Levy, D. (Daniel) Grossmann, V. (Vera) Patel, K.V. (Kushang V.) Chen, C.-H. Ridker, P.M. (Paul M.) Tang, H. (Hua) Launer, L.J. (Lenore) Rice, K.M. (Kenneth M.) Li-Gao, R. (Ruifang) Ferrucci, L. (Luigi) Evans, M.K. (Michelle K.) Choudhuri, A. (Avik) Trompouki, E. (Eirini) Abraham, B.J. (Brian J.) Yang, S. (Song) Takahashi, A. (Atsushi) Kamatani, Y. (Yoichiro) Kooperberg, C. (Charles) Harris, T.B. (Tamara) Jee, S.H. (Sun Ha) Coresh, J. (Josef) Tsai, F.-J. (Fuu-Jen) Longo, D.L. (Dan L.) Chen, Y.-T. (Yuan-Tsong) Felix, J.F. (Janine) Yang, Q. (Qiong) Psaty, B.M. (Bruce) Boerwinkle, E.A. (Eric) Becker, L.C. (Lewis C.) Mook-Kanamori, D.O. (Dennis) Wilson, J.F. (James) Gudnason, V. (Vilmundur) O'Donnell, C.J. (Christopher J.) Dehghan, A. (Abbas) Cupples, L.A. (Adrienne) Nalls, M.A. (Michael) Morris, A.P. (Andrew) Okada, Y. (Yukinori) Reiner, A.P. (Alexander P.) Zon, L.I. (Leonard) Ganesh, S.K. (Santhi) Rooij, F.J.A. (Frank) van Qayyum, Q. (Rehan) Smith, A.V. (Albert Vernon) Zhou, Y. (Yi) Trompet, S. (Stella) Tanaka, T. (Toshiko) Keller, M.F. (Margaux) Chang, L.-C. (Li-Ching) Schmidt, H. (Helena) Yang, M.-L. (Min-Lee) Chen, M.-H. (Ming-Huei) Hayes, J. (James) Johnson, A.D. (Andrew) Yanek, L.R. (Lisa) Mueller, C. (Christian) Lange, L.A. (Leslie) Floyd, J. (James) Ghanbari, M. (Mohsen) Zonderman, A.B. Jukema, J.W. Hofman, A. (Albert) Duijn, C.M. (Cornelia) van Desch, K.C. (Karl C.) Saba, Y. (Yasaman) Ozel, A.B. (Ayse) Snively, B.M. (Beverly M.) Wu, J.-Y. (Jer-Yuarn) Schmidt, R. (Reinhold) Fornage, M. (Myriam) Klein, R.J. (Robert J.) Fox, C.S. (Caroline) Matsuda, K. (Koichi) Kamatani, N. (Naoyuki) Wild, P.S. (Philipp S.) Stott, D.J. (David J.) Ford, I. Slagboom, P.E. (Eline) Yang, J. (Jaden) Chu, A.Y. (Audrey Y) Lambert, A.J. (Amy J.) Uitterlinden, A.G. (André) Franco, O.H. (Oscar) Hofer, E. (Edith) Ginsburg, D. (David) Hu, B. (Bella) Keating, J. (John) Schick, U.M. (Ursula) Brody, J.A. (Jennifer A.) Li, J.Z. (Jun Z.) Chen, Z. (Zhao) Zeller, T. (Tanja) Guralnik, J.M. (Jack M.) Chasman, D.I. (Daniel) Peters, L.L. (Luanne L.) Kubo, M. (Michiaki) Becker, D.M. (Diane M.) Li, J. (Jin) Eiriksdottir, G. (Gudny) Rotter, J.I. (Jerome I.) Levy, D. (Daniel) Grossmann, V. (Vera) Patel, K.V. (Kushang V.) Chen, C.-H. Ridker, P.M. (Paul M.) Tang, H. (Hua) Launer, L.J. (Lenore) Rice, K.M. (Kenneth M.) Li-Gao, R. (Ruifang) Ferrucci, L. (Luigi) Evans, M.K. (Michelle K.) Choudhuri, A. (Avik) Trompouki, E. (Eirini) Abraham, B.J. (Brian J.) Yang, S. (Song) Takahashi, A. (Atsushi) Kamatani, Y. (Yoichiro) Kooperberg, C. (Charles) Harris, T.B. (Tamara) Jee, S.H. (Sun Ha) Coresh, J. (Josef) Tsai, F.-J. (Fuu-Jen) Longo, D.L. (Dan L.) Chen, Y.-T. (Yuan-Tsong) Felix, J.F. (Janine) Yang, Q. (Qiong) Psaty, B.M. (Bruce) Boerwinkle, E.A. (Eric) Becker, L.C. (Lewis C.) Mook-Kanamori, D.O. (Dennis) Wilson, J.F. (James) Gudnason, V. (Vilmundur) O'Donnell, C.J. (Christopher J.) Dehghan, A. (Abbas) Cupples, L.A. (Adrienne) Nalls, M.A. (Michael) Morris, A.P. (Andrew) Okada, Y. (Yukinori) Reiner, A.P. (Alexander P.) Zon, L.I. (Leonard) Ganesh, S.K. (Santhi)
Publication Year :
2017
Abstract
Genome-wide association studies (GWASs) have identified loci for erythrocyte traits in primarily European ancestry populations. We conducted GWAS meta-analyses of six erythrocyte traits in 71,638 individuals from European, East Asian, and African ancestries using a Bayesian approach to account for heterogeneity in allelic effects and variation in the structure of linkage disequilibrium between ethnicities. We identified seven loci for erythrocyte traits including a locus (RBPM
Details
Database :
OAIster
Notes :
American Journal of Human Genetics vol. 100 no. 1, pp. 51-63, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1042809120
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1016.j.ajhg.2016.11.016