Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia

Background: Total hippocampal volume has been consistently linked to cognitive function and dementia. Yet, given its complex and parcellated internal structure, the role of subregions of the hippocampus in cognition and risk of dementia remains relatively underexplored. We studied subregions of the hippocampus in a large population-based cohort to further understand their role in cognitive impairment and dementia risk. Methods: We studied 5035 dementia- and stroke-free persons from the Rotterdam Study, aged over 45 year