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Recognition of Plasmodium falciparum mature gametocyte-infected erythrocytes by antibodies of semi-immune adults and malaria-exposed children from Gabon

Authors :
Gebru, Tamirat
Ajua, Anthony
Theisen, Michael
Esen, Meral
Ngoa, Ulysse Ateba
Issifou, Saadou
Adegnika, Ayola Akim
Kremsner, Peter G
Mordmüller, Benjamin
Held, Jana
Gebru, Tamirat
Ajua, Anthony
Theisen, Michael
Esen, Meral
Ngoa, Ulysse Ateba
Issifou, Saadou
Adegnika, Ayola Akim
Kremsner, Peter G
Mordmüller, Benjamin
Held, Jana
Source :
Gebru , T , Ajua , A , Theisen , M , Esen , M , Ngoa , U A , Issifou , S , Adegnika , A A , Kremsner , P G , Mordmüller , B & Held , J 2017 , ' Recognition of Plasmodium falciparum mature gametocyte-infected erythrocytes by antibodies of semi-immune adults and malaria-exposed children from Gabon ' , Malaria Journal , vol. 16 , 176 .
Publication Year :
2017

Abstract

BACKGROUND: Transmission of malaria from man to mosquito depends on the presence of gametocytes, the sexual stage of Plasmodium parasites in the infected host. Naturally acquired antibodies against gametocytes exist and may play a role in controlling transmission by limiting the gametocyte development in the circulation or by interrupting gamete development and fertilization in the mosquito following ingestion. So far, most studies on antibody responses to sexual stage antigens have focused on a subset of gametocyte-surface antigens, even though inhibitory Ab responses to other gametocyte antigens might also play a role in controlling gametocyte density and fertility. Limited information is available on natural antibody response to the surfaces of gametocyte-infected erythrocytes.METHODS: Ab responses to surface antigens of erythrocytes infected by in vitro differentiated Plasmodium falciparum mature gametocytes were investigated in sera of semi-immune adults and malaria-exposed children. In addition, the effect of immunization with GMZ2, a blood stage malaria vaccine candidate, and the effect of intestinal helminth infection on the development of immunity to gametocytes of P. falciparum was evaluated in malaria-exposed children and adults from Gabon. Serum samples from two Phase I clinical trials conducted in Gabon were analysed by microscopic and flow-cytometric immunofluorescence assay.RESULTS: Adults had a higher Ab response compared to children. Ab reactivity was significantly higher after fixation and permeabilization of parasitized erythrocytes. Following vaccination with the malaria vaccine candidate GMZ2, anti-gametocyte Ab concentration decreased in adults compared to baseline. Ab response to whole asexual stage antigens had a significant but weak positive correlation to anti-gametocyte Ab responses in adults, but not in children. Children infected with Ascaris lumbricoides had a significantly higher anti-gametocyte Ab response compared to

Details

Database :
OAIster
Journal :
Gebru , T , Ajua , A , Theisen , M , Esen , M , Ngoa , U A , Issifou , S , Adegnika , A A , Kremsner , P G , Mordmüller , B & Held , J 2017 , ' Recognition of Plasmodium falciparum mature gametocyte-infected erythrocytes by antibodies of semi-immune adults and malaria-exposed children from Gabon ' , Malaria Journal , vol. 16 , 176 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1048266314
Document Type :
Electronic Resource