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Utility of the Hebb–Williams maze paradigm for translational research in Fragile X syndrome: A direct comparison of mice and humans
- Source :
- Frontiers in Molecular Neuroscience vol. 11
- Publication Year :
- 2018
-
Abstract
- To generate meaningful information, translational research must employ paradigms that allow extrapolation from animal models to humans. However, few studies have evaluated translational paradigms on the basis of defined validation criteria. We outline three criteria for validating translational paradigms. We then evaluate the Hebb–Williams maze paradigm (Hebb and Williams, 1946; Rabinovitch and Rosvold, 1951) on the basis of these criteria using Fragile X syndrome (FXS) as model disease. We focused
Details
- Database :
- OAIster
- Journal :
- Frontiers in Molecular Neuroscience vol. 11
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1051044323
- Document Type :
- Electronic Resource
- Full Text :
- https://doi.org/10.3389.fnmol.2018.00099