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Large-scale transcriptome-wide association study identifies new prostate cancer risk regions

Authors :
Mancuso, N. (Nicholas)
Gayther, S.A. (Simon)
Gusev, A. (Alexander)
Zheng, W. (Wei)
Penney, K.L. (Kathryn L.)
Kote-Jarai, Z.
Eeles, R. (Rosalind)
Freedman, M. (Matthew)
Haiman, C.A. (Christopher)
Pasaniuc, B. (Bogdan)
Henderson, B.E. (Brian)
Benlloch, S. (Sara)
Schumacher, F. (Fredrick)
Olama, A.A.A. (Ali Amin Al)
Muir, K. (Kenneth)
Berndt, S.I. (Sonja)
Conti, G. (Giario)
Wiklund, F. (Fredrik)
Chanock, S.J. (Stephen)
Stevens, V.L. (Victoria L.)
Tangen, C.M. (Catherine M.)
Batra, J. (Jyotsna)
Clements, J. (Judith)
Grönberg, H. (Henrik)
Pashayan, N. (Nora)
Schleutker, J. (Johanna)
Albanes, D. (Demetrius)
Weinstein, S. (Stephanie)
Wolk, K. (Kerstin)
West, C. (Catharine)
Mucci, L. (Lorelei)
Cancel-Tassin, G. (Géraldine)
Koutros, S. (Stella)
Sorensen, K.D. (Karina Dalsgaard)
Maehle, L.
Neal, D. (David)
Hamdy, F. (Freddie)
Donovan, J. (Jenny)
Travis, S.P.L. (Simon)
Hamilton, R.J. (Robert J.)
Ingles, S.A. (Sue)
Rosenstein, B.S. (Barry S.)
Lu, Y.-J. (Yong-Jie)
Giles, G.G. (Graham G.)
Kibel, A. (Adam)
Vega, A. (Ana)
Kogevinas, M. (Manolis)
Park, J.Y. (Jong Y.)
Stanford, J.L. (Janet L.)
Cybulski, C. (Cezary)
Nordestgaard, B.G. (Børge)
Brenner, H. (Hermann)
Maier, C. (Christiane)
Kim, J. (Jongoh)
John, E.M. (Esther)
Teixeira, P.J.
Neuhausen, S.L. (Susan)
De Ruyck, K. (Kim)
Razack, A. (Azad)
Newcomb, L.F. (Lisa F.)
Lessel, D. (Davor)
Kaneva, R. (Radka)
Usmani, N. (Nawaid)
Claessens, F. (Frank)
Townsend, P.A. (Paul A.)
Dominguez, M.G. (Manuela Gago)
Roobol-Bouts, M.J. (Monique)
Menegaux, F. (Florence)
Khaw, K.-T. (Kay-Tee)
Cannon-Albright, L.A. (Lisa)
Pandha, H. (Hardev)
Thibodeau, S.N. (Stephen N.)
Hunter, D.J. (David J.)
Kraft, P. (Peter)
Mancuso, N. (Nicholas)
Gayther, S.A. (Simon)
Gusev, A. (Alexander)
Zheng, W. (Wei)
Penney, K.L. (Kathryn L.)
Kote-Jarai, Z.
Eeles, R. (Rosalind)
Freedman, M. (Matthew)
Haiman, C.A. (Christopher)
Pasaniuc, B. (Bogdan)
Henderson, B.E. (Brian)
Benlloch, S. (Sara)
Schumacher, F. (Fredrick)
Olama, A.A.A. (Ali Amin Al)
Muir, K. (Kenneth)
Berndt, S.I. (Sonja)
Conti, G. (Giario)
Wiklund, F. (Fredrik)
Chanock, S.J. (Stephen)
Stevens, V.L. (Victoria L.)
Tangen, C.M. (Catherine M.)
Batra, J. (Jyotsna)
Clements, J. (Judith)
Grönberg, H. (Henrik)
Pashayan, N. (Nora)
Schleutker, J. (Johanna)
Albanes, D. (Demetrius)
Weinstein, S. (Stephanie)
Wolk, K. (Kerstin)
West, C. (Catharine)
Mucci, L. (Lorelei)
Cancel-Tassin, G. (Géraldine)
Koutros, S. (Stella)
Sorensen, K.D. (Karina Dalsgaard)
Maehle, L.
Neal, D. (David)
Hamdy, F. (Freddie)
Donovan, J. (Jenny)
Travis, S.P.L. (Simon)
Hamilton, R.J. (Robert J.)
Ingles, S.A. (Sue)
Rosenstein, B.S. (Barry S.)
Lu, Y.-J. (Yong-Jie)
Giles, G.G. (Graham G.)
Kibel, A. (Adam)
Vega, A. (Ana)
Kogevinas, M. (Manolis)
Park, J.Y. (Jong Y.)
Stanford, J.L. (Janet L.)
Cybulski, C. (Cezary)
Nordestgaard, B.G. (Børge)
Brenner, H. (Hermann)
Maier, C. (Christiane)
Kim, J. (Jongoh)
John, E.M. (Esther)
Teixeira, P.J.
Neuhausen, S.L. (Susan)
De Ruyck, K. (Kim)
Razack, A. (Azad)
Newcomb, L.F. (Lisa F.)
Lessel, D. (Davor)
Kaneva, R. (Radka)
Usmani, N. (Nawaid)
Claessens, F. (Frank)
Townsend, P.A. (Paul A.)
Dominguez, M.G. (Manuela Gago)
Roobol-Bouts, M.J. (Monique)
Menegaux, F. (Florence)
Khaw, K.-T. (Kay-Tee)
Cannon-Albright, L.A. (Lisa)
Pandha, H. (Hardev)
Thibodeau, S.N. (Stephen N.)
Hunter, D.J. (David J.)
Kraft, P. (Peter)
Publication Year :
2018

Abstract

Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS (N = 142,392) with gene expression measured in 45 tissues (N = 4458), including normal and tumor prostate, to perform a multi-tissue transcriptome-wide association study (TWAS) for PrCa. We identify 217 genes at 84 independent 1 Mb regions associated with PrCa risk, 9 of which are regions

Details

Database :
OAIster
Notes :
application/pdf, Nature Communications vol. 9 no. 1, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1081018524
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41467-018-06302-1
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