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Synthesis and application of branched type II arabinogalactans
- Source :
- Andersen , M C F , Boos , I , Ruprecht , C , Willats , W G T , Pfrengle , F & Clausen , M H 2017 , ' Synthesis and application of branched type II arabinogalactans ' , Journal of organic chemistry , vol. 82 , no. 23 , pp. 12066–12084 .
- Publication Year :
- 2017
-
Abstract
- The synthesis of linear- and (1→6)-branched β-(1→3)-D-galactans, structures found in plant arabinogalactan proteins (AGPs) is described. The synthetic strategy relies on iterative couplings of mono- and disaccharide thioglycoside donors, followed by a late stage glycosylation of heptagalactan backbone acceptors to introduce branching. A key finding from the synthetic study was the need to match protective groups in order to tune reactivity and ensure selectivity during the assembly. Carbohydrate microarrays were generated to enable the detailed epitope mapping of two monoclonal antibodies known to recognize AGPs: JIM16 and JIM133.
Details
- Database :
- OAIster
- Journal :
- Andersen , M C F , Boos , I , Ruprecht , C , Willats , W G T , Pfrengle , F & Clausen , M H 2017 , ' Synthesis and application of branched type II arabinogalactans ' , Journal of organic chemistry , vol. 82 , no. 23 , pp. 12066–12084 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1083511914
- Document Type :
- Electronic Resource