Different risk factors for cognitive impairment among community-dwelling elderly, with impaired fasting glucose or diabetes

Shuangling Xiu,1,2 Zheng Zheng,3–6 Qiuju Liao,2 Piu Chan2–8 1Department of Endocrinology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; 2National Clinical Research Center for Geriatric Disorders, Beijing 100053, China; 3Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; 4Parkinson’s Disease Center of Beijing Institute for Brain Disorders, Beijing 100069, China; 5Key Laboratory on Neurodegenerative Disease of Ministry of Education, Capital Medical University, Beijing 100069, China; 6Beijing Key Laboratory for Parkinson’s Disease, Beijing 100053, China; 7Department of Geriatrics, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China; 8Department of Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China Aim: The aim of this study was to investigate whether elderly people with impaired fasting glucose (IFG) or diabetes mellitus (DM) share the common risk factors for cognitive impairment as compared to normal blood glucose population.Methods: This cross-sectional study assessed 10,039 community-dwelling participants aged ≥ 55 years in Beijing, China. According to the glycemic status, subjects were classified into three groups: normal fasting plasma glucose (NG, n=6399), impaired fasting glucose (IFG, n=873) and DM (n=2626). The Mini-Mental State Examination (MMSE) was applied to evaluate the cognitive function status of the study population. Potential demographic, clinical, and genetic risk factors for cognitive impairment were collected and compared across the three groups. Multivariate logistic regression model was performed to explore the risk factors associated with cognitive impairment.Results: Education-modified MMSE scores in the participants with NG, IFG, and DM were 26