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The prognostic role of circulating tumor cells (CTCs) in lung cancer

Authors :
Kapeleris, Joanna
Kulasinghe, Arutha
Ebrahimi Warkiani, Majid
Vela, Ian
Kenny, Lizbeth
O'Byrne, Ken
Punyadeera, Chamindie
Kapeleris, Joanna
Kulasinghe, Arutha
Ebrahimi Warkiani, Majid
Vela, Ian
Kenny, Lizbeth
O'Byrne, Ken
Punyadeera, Chamindie
Source :
Frontiers in Oncology
Publication Year :
2018

Abstract

Lung cancer affects over 1. 8 million people worldwide and is the leading cause of cancer related mortality globally. Currently, diagnosis of lung cancer involves a combination of imaging and invasive biopsies to confirm histopathology. Non-invasive diagnostic techniques under investigation include “liquid biopsies” through a simple blood draw to develop predictive and prognostic biomarkers. A better understanding of circulating tumor cell (CTC) dissemination mechanisms offers promising potential for the development of techniques to assist in the diagnosis of lung cancer. Enumeration and characterization of CTCs has the potential to act as a prognostic biomarker and to identify novel drug targets for a precision medicine approach to lung cancer care. This review will focus on the current status of CTCs and their potential diagnostic and prognostic utility in this setting.

Details

Database :
OAIster
Journal :
Frontiers in Oncology
Notes :
application/pdf
Publication Type :
Electronic Resource
Accession number :
edsoai.on1089455563
Document Type :
Electronic Resource