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The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity

Authors :
Alonso De Diego, Sergio A.
Gutiérrez-Rodríguez, Marta
Pérez de Vega, M. Jesús
González-Muñiz, Rosario
Herranz, Rosario
Martín-Martínez, Mercedes
Cenarruzabeitia, Edurne
Frechilla, Diana
Río, Joaquín del
Jimeno, M. Luisa
García-López, M. Teresa
Alonso De Diego, Sergio A.
Gutiérrez-Rodríguez, Marta
Pérez de Vega, M. Jesús
González-Muñiz, Rosario
Herranz, Rosario
Martín-Martínez, Mercedes
Cenarruzabeitia, Edurne
Frechilla, Diana
Río, Joaquín del
Jimeno, M. Luisa
García-López, M. Teresa
Publication Year :
2006

Abstract

The influence of several modifications on the GPE tripeptide structure upon the binding to GluRs and on their neuroprotective effects has been studied. The results indicated that the prevention of neuronal death showed by GPE and some analogues is not directly related to their affinity at glutamate receptors.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1103366219
Document Type :
Electronic Resource