Back to Search Start Over

Years of life that could be saved from prevention of hepatocellular carcinoma

Authors :
Cucchetti, A
Trevisani, F.
Bucci, L.
Ravaioli, M.
Farinati, F.
Giannini, E. G.
Ciccarese, F.
Piscaglia, F.
Rapaccini, Gian Ludovico
Di Marco, M.
Caturelli, E.
Zoli, M.
Borzio, F.
Sacco, R.
Maida, M.
Felder, M.
Morisco, F.
Gasbarrini, Antonio
Gemini, S.
Foschi, F. G.
Missale, G.
Masotto, A.
Affronti, A.
Bernardi, M.
Pinna, A. D.
Bolondi, Luigi
Biselli, Maurizio
Caraceni, Paolo
Domenicali, Marco
Gramenzi, Annagiulia
Magalotti, Donatella
Pecorelli, Anna
Serra, Carla
Venerandi, Laura
Gazzola, Alessia
Murer, Francesca
Pozzan, Caterina
Vanin, Veronica
Del Poggio, Paolo
Olmi, Stefano
Balsamo, Claudia
Vavassori, Elena
Benvegnù, Luisa
Cappelli, Alberta
Golfieri, Rita
Mosconi, Cristina
Renzulli, Matteo
Bosco, Giulia
Roselli, Paola
Dell'Isola, Serena
Lalungo, Anna Maria
Rastrelli, Elena
Moscatelli, Alessandro
Pellegatta, Gaia
Picciotto, Antonino
Savarino, Vincenzo
Barcellona, Maria Rosa
Cammà, Calogero
Cabibbo, Giuseppe
Costantino, Andrea
Virdone, Roberto
Mega, Andrea
Rinninella, Emanuele
Mismas, Valeria
Dall'Aglio, Anna Chiara
Feletti, Valentina
Lanzi, Arianna
Cappa, Federica Mirici
Neri, Elga
Stefanini, Giuseppe Francesco
Tamberi, Stefano
Biasini, Elisabetta
Porro, Emanuela
Guarino, Maria
Baroni, Gianluca Svegliati
Schiadà, Laura
Chiaramonte, Maria
Marchetti, Fabiana
Valerio, Matteo
Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X)
Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Rinninella, Emanuele (ORCID:0000-0002-9165-2367)
Cucchetti, A
Trevisani, F.
Bucci, L.
Ravaioli, M.
Farinati, F.
Giannini, E. G.
Ciccarese, F.
Piscaglia, F.
Rapaccini, Gian Ludovico
Di Marco, M.
Caturelli, E.
Zoli, M.
Borzio, F.
Sacco, R.
Maida, M.
Felder, M.
Morisco, F.
Gasbarrini, Antonio
Gemini, S.
Foschi, F. G.
Missale, G.
Masotto, A.
Affronti, A.
Bernardi, M.
Pinna, A. D.
Bolondi, Luigi
Biselli, Maurizio
Caraceni, Paolo
Domenicali, Marco
Gramenzi, Annagiulia
Magalotti, Donatella
Pecorelli, Anna
Serra, Carla
Venerandi, Laura
Gazzola, Alessia
Murer, Francesca
Pozzan, Caterina
Vanin, Veronica
Del Poggio, Paolo
Olmi, Stefano
Balsamo, Claudia
Vavassori, Elena
Benvegnù, Luisa
Cappelli, Alberta
Golfieri, Rita
Mosconi, Cristina
Renzulli, Matteo
Bosco, Giulia
Roselli, Paola
Dell'Isola, Serena
Lalungo, Anna Maria
Rastrelli, Elena
Moscatelli, Alessandro
Pellegatta, Gaia
Picciotto, Antonino
Savarino, Vincenzo
Barcellona, Maria Rosa
Cammà, Calogero
Cabibbo, Giuseppe
Costantino, Andrea
Virdone, Roberto
Mega, Andrea
Rinninella, Emanuele
Mismas, Valeria
Dall'Aglio, Anna Chiara
Feletti, Valentina
Lanzi, Arianna
Cappa, Federica Mirici
Neri, Elga
Stefanini, Giuseppe Francesco
Tamberi, Stefano
Biasini, Elisabetta
Porro, Emanuela
Guarino, Maria
Baroni, Gianluca Svegliati
Schiadà, Laura
Chiaramonte, Maria
Marchetti, Fabiana
Valerio, Matteo
Rapaccini, Gian Ludovico (ORCID:0000-0002-6467-857X)
Gasbarrini, Antonio (ORCID:0000-0002-7278-4823)
Rinninella, Emanuele (ORCID:0000-0002-9165-2367)
Publication Year :
2016

Abstract

Background: Hepatocellular carcinoma (HCC) causes premature death and loss of life expectancy worldwide. Its primary and secondary prevention can result in a significant number of years of life saved. Aim: To assess how many years of life are lost after HCC diagnosis. Methods: Data from 5346 patients with first HCC diagnosis were used to estimate lifespan and number of years of life lost after tumour onset, using a semi-parametric extrapolation having as reference an age-, sex- and year-of-onset-matched population derived from national life tables. Results: Between 1986 and 2014, HCC lead to an average of 11.5 years-of-life lost for each patient. The youngest age-quartile group (18-61 years) had the highest number of years-of-life lost, representing approximately 41% of the overall benefit obtainable from prevention. Advancements in HCC management have progressively reduced the number of years-of-life lost from 12.6 years in 1986-1999, to 10.7 in 2000-2006 and 7.4 years in 2007-2014. Currently, an HCC diagnosis when a single tumour <2 cm results in 3.7 years-of-life lost while the diagnosis when a single tumour ≥2 cm or 2/3 nodules still within the Milan criteria, results in 5.0 years-of-life lost, representing the loss of only approximately 5.5% and 7.2%, respectively, of the entire lifespan from birth. Conclusions: Hepatocellular carcinoma occurrence results in the loss of a considerable number of years-of-life, especially for younger patients. In recent years, the increased possibility of effectively treating this tumour has improved life expectancy, thus reducing years-of-life lost.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1105029045
Document Type :
Electronic Resource