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Shared heritability and functional enrichment across six solid cancers.
Authors :
Jiang, X Finucane, Hk Schumacher, Fr Schmit, Sl Tyrer, Jp Han, Y Michailidou, K Lesseur, C Kuchenbaecker, Kb Dennis, J Conti, Dv Casey, G Gaudet, Mm Huyghe, Jr Albanes, D Aldrich, Mc Andrew, A Andrulis, Il Anton-Culver, H Antoniou, Ac Antonenkova, Nn Arnold, Sm Aronson, Kj Arun, Bk Bandera, Ev Barkardottir, Rb Barnes, Dr Batra, J Beckmann, Mw Benitez, J Benlloch, S Berchuck, A Berndt, Si Bickeböller, H Bien, Sa Blomqvist, C Boccia, Stefania Bogdanova, Nv Bojesen, Se Bolla, Mk Brauch, H Brenner, H Brenton, Jd Brook, Mn Brunet, J Brunnström, H Buchanan, Dd Burwinkel, B Butzow, R Cadoni, Gabriella Caldés, T Caligo, Ma Campbell, I Campbell, Pt Cancel-Tassin, G Cannon-Albright, L Campa, D Caporaso, N Carvalho, Al Chan, At Chang-Claude, J Chanock, Sj Chen, C Christiani, Dc Claes, Kbm Claessens, F Clements, J Collée, Jm Correa, Mc Couch, Fj Cox, A Cunningham, Jm Cybulski, C Czene, K Daly, Mb Defazio, A Devilee, P Diez, O Gago-Dominguez, M Donovan, Jl Dörk, T Duell, Ej Dunning, Am Dwek, M Eccles, Dm Edlund, Ck Edwards, Drv Ellberg, C Evans, Dg Fasching, Pa Ferris, Rl Liloglou, T Figueiredo, Jc Fletcher, O Fortner, Rt Fostira, F Franceschi, S Friedman, E Gallinger, Sj Ganz, Pa Garber, J García-Sáenz, Ja Gayther, Sa Giles, Gg Godwin, Ak Goldberg, M Goldgar, De Goode, El Goodman, Mt Goodman, G Grankvist, K Greene, Mh Gronberg, H Gronwald, J Guénel, P Håkansson, N Hall, P Hamann, U Hamdy, Fc Hamilton, Rj Hampe, J Haugen, A Heitz, F Herrero, R Hillemanns, P Hoffmeister, M Høgdall, E Hong, Yc Hopper, Jl Houlston, R Hulick, Pj Hunter, Dj Huntsman, Dg Idos, G Imyanitov, En Ingles, Sa Isaacs, C Jakubowska, A James, P Jenkins, Ma Johansson, M John, Em Joshi, Ad Kaneva, R Karlan, By Kelemen, Le Kühl, T Khaw, Kt Khusnutdinova, E Kibel, A Kiemeney, La Kim, J Kjaer, Sk Knight, Ja Kogevinas, M Kote-Jarai, Z Koutros, S Kristensen, Vn Kupryjanczyk, J Lacko, M Lam, S Lambrechts, D Landi, Mt Lazarus, P Le, Nd Lee, E Lejbkowicz, F Lenz, Hj Leslie, G Lessel, D Lester, J Levine, Da Li, L Li, Ci Lindblom, A Lindor, Nm Liu, G Loupakis, F Lubiński, J Maehle, L Maier, C Mannermaa, A Marchand, Ll Margolin, S May, T Mcguffog, L Meindl, A Middha, P Miller, A Milne, Rl Macinnis, Rj Modugno, F Montagna, M Moreno, V Moysich, Kb Mucci, L Muir, K Mulligan, Am Nathanson, Kl Neal, De Ness, Ar Neuhausen, Sl Nevanlinna, H Newcomb, Pa Newcomb, Lf Nielsen, Fc Nikitina-Zake, L Nordestgaard, Bg Nussbaum, Rl Offit, K Olah, E Olama, Aaa Olopade, Oi Olshan, Af Olsson, H Osorio, A Pandha, H Park, Jy Pashayan, N Parsons, Mt Pejovic, T Penney, Kl Peters, Whm Phelan, Cm Phipps, Ai Plaseska-Karanfilska, D Pring, M Prokofyeva, D Radice, P Stefansson, K Ramus, Sj Raskin, L Rennert, G Rennert, H van Rensburg, Ej Riggan, Mj Risch, Ha Risch, A Roobol, Mj Rosenstein, B Rossing, Ma De Ruyck, K Saloustros, E Sandler, Dp Sawyer, Ej Schabath, Mb Schleutker, J Schmidt, Mk Setiawan, Vw Shen, H Siegel, Em Sieh, W Singer, Cf Slattery, Ml Sorensen, Kd Southey, Mc Spurdle, Ab Stanford, Jl Stevens, Vl Stintzing, S Stone, J Sundfeldt, K Sutphen, R Swerdlow, Aj Tajara, Eh Tangen, Cm Tardon, A Taylor, Ja Teare, Md Teixeira, Mr Terry, Mb Terry, Kl Thibodeau, Sn Thomassen, M Bjørge, L Tischkowitz, M Toland, Ae Torres, D Townsend, Pa Travis, Rc Tung, N Tworoger, S Ulrich, Cm Usmani, N Vachon, Cm Van Nieuwenhuysen, E Vega, A Aguado-Barrera, Me Wang, Q Webb, Pm Weinberg, Cr Weinstein, S Weissler, Mc Weitzel, Jn West, Cml White, E Whittemore, A Wichmann, He Wiklund, F Winqvist, R Wolk, A Woll, P Woods, M Wu, Ah Wu, X Yannoukakos, D Zheng, W Zienolddiny, S Ziogas, A Zorn, Kk Lane, Jm Saxena, R Thomas, D Hung, Rj Diergaarde, B Mckay, J Peters, U Hsu, L García-Closas, M Eeles, Ra Chenevix-Trench, G Brennan, Pj Haiman, Ca Simard, J Easton, Df Gruber, Sb Pharoah, Pdp Price, Al Pasaniuc, B Amos, Ci Kraft, P Lindström, S. Boccia S (ORCID:0000-0002-1864-749X) Cadoni G (ORCID:0000-0001-8244-784X) Jiang, X Finucane, Hk Schumacher, Fr Schmit, Sl Tyrer, Jp Han, Y Michailidou, K Lesseur, C Kuchenbaecker, Kb Dennis, J Conti, Dv Casey, G Gaudet, Mm Huyghe, Jr Albanes, D Aldrich, Mc Andrew, A Andrulis, Il Anton-Culver, H Antoniou, Ac Antonenkova, Nn Arnold, Sm Aronson, Kj Arun, Bk Bandera, Ev Barkardottir, Rb Barnes, Dr Batra, J Beckmann, Mw Benitez, J Benlloch, S Berchuck, A Berndt, Si Bickeböller, H Bien, Sa Blomqvist, C Boccia, Stefania Bogdanova, Nv Bojesen, Se Bolla, Mk Brauch, H Brenner, H Brenton, Jd Brook, Mn Brunet, J Brunnström, H Buchanan, Dd Burwinkel, B Butzow, R Cadoni, Gabriella Caldés, T Caligo, Ma Campbell, I Campbell, Pt Cancel-Tassin, G Cannon-Albright, L Campa, D Caporaso, N Carvalho, Al Chan, At Chang-Claude, J Chanock, Sj Chen, C Christiani, Dc Claes, Kbm Claessens, F Clements, J Collée, Jm Correa, Mc Couch, Fj Cox, A Cunningham, Jm Cybulski, C Czene, K Daly, Mb Defazio, A Devilee, P Diez, O Gago-Dominguez, M Donovan, Jl Dörk, T Duell, Ej Dunning, Am Dwek, M Eccles, Dm Edlund, Ck Edwards, Drv Ellberg, C Evans, Dg Fasching, Pa Ferris, Rl Liloglou, T Figueiredo, Jc Fletcher, O Fortner, Rt Fostira, F Franceschi, S Friedman, E Gallinger, Sj Ganz, Pa Garber, J García-Sáenz, Ja Gayther, Sa Giles, Gg Godwin, Ak Goldberg, M Goldgar, De Goode, El Goodman, Mt Goodman, G Grankvist, K Greene, Mh Gronberg, H Gronwald, J Guénel, P Håkansson, N Hall, P Hamann, U Hamdy, Fc Hamilton, Rj Hampe, J Haugen, A Heitz, F Herrero, R Hillemanns, P Hoffmeister, M Høgdall, E Hong, Yc Hopper, Jl Houlston, R Hulick, Pj Hunter, Dj Huntsman, Dg Idos, G Imyanitov, En Ingles, Sa Isaacs, C Jakubowska, A James, P Jenkins, Ma Johansson, M John, Em Joshi, Ad Kaneva, R Karlan, By Kelemen, Le Kühl, T Khaw, Kt Khusnutdinova, E Kibel, A Kiemeney, La Kim, J Kjaer, Sk Knight, Ja Kogevinas, M Kote-Jarai, Z Koutros, S Kristensen, Vn Kupryjanczyk, J Lacko, M Lam, S Lambrechts, D Landi, Mt Lazarus, P Le, Nd Lee, E Lejbkowicz, F Lenz, Hj Leslie, G Lessel, D Lester, J Levine, Da Li, L Li, Ci Lindblom, A Lindor, Nm Liu, G Loupakis, F Lubiński, J Maehle, L Maier, C Mannermaa, A Marchand, Ll Margolin, S May, T Mcguffog, L Meindl, A Middha, P Miller, A Milne, Rl Macinnis, Rj Modugno, F Montagna, M Moreno, V Moysich, Kb Mucci, L Muir, K Mulligan, Am Nathanson, Kl Neal, De Ness, Ar Neuhausen, Sl Nevanlinna, H Newcomb, Pa Newcomb, Lf Nielsen, Fc Nikitina-Zake, L Nordestgaard, Bg Nussbaum, Rl Offit, K Olah, E Olama, Aaa Olopade, Oi Olshan, Af Olsson, H Osorio, A Pandha, H Park, Jy Pashayan, N Parsons, Mt Pejovic, T Penney, Kl Peters, Whm Phelan, Cm Phipps, Ai Plaseska-Karanfilska, D Pring, M Prokofyeva, D Radice, P Stefansson, K Ramus, Sj Raskin, L Rennert, G Rennert, H van Rensburg, Ej Riggan, Mj Risch, Ha Risch, A Roobol, Mj Rosenstein, B Rossing, Ma De Ruyck, K Saloustros, E Sandler, Dp Sawyer, Ej Schabath, Mb Schleutker, J Schmidt, Mk Setiawan, Vw Shen, H Siegel, Em Sieh, W Singer, Cf Slattery, Ml Sorensen, Kd Southey, Mc Spurdle, Ab Stanford, Jl Stevens, Vl Stintzing, S Stone, J Sundfeldt, K Sutphen, R Swerdlow, Aj Tajara, Eh Tangen, Cm Tardon, A Taylor, Ja Teare, Md Teixeira, Mr Terry, Mb Terry, Kl Thibodeau, Sn Thomassen, M Bjørge, L Tischkowitz, M Toland, Ae Torres, D Townsend, Pa Travis, Rc Tung, N Tworoger, S Ulrich, Cm Usmani, N Vachon, Cm Van Nieuwenhuysen, E Vega, A Aguado-Barrera, Me Wang, Q Webb, Pm Weinberg, Cr Weinstein, S Weissler, Mc Weitzel, Jn West, Cml White, E Whittemore, A Wichmann, He Wiklund, F Winqvist, R Wolk, A Woll, P Woods, M Wu, Ah Wu, X Yannoukakos, D Zheng, W Zienolddiny, S Ziogas, A Zorn, Kk Lane, Jm Saxena, R Thomas, D Hung, Rj Diergaarde, B Mckay, J Peters, U Hsu, L García-Closas, M Eeles, Ra Chenevix-Trench, G Brennan, Pj Haiman, Ca Simard, J Easton, Df Gruber, Sb Pharoah, Pdp Price, Al Pasaniuc, B Amos, Ci Kraft, P Lindström, S. Boccia S (ORCID:0000-0002-1864-749X) Cadoni G (ORCID:0000-0001-8244-784X)
Publication Year :
2019
Abstract
Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1105035622
Document Type :
Electronic Resource