A Convenient Way to Fabricate Microneedle Array Based on UV Lithography via Microlens Technique

In this paper, we have developed a simple and direct platform to fabricate tapered microneedle (MN) structures using UV lithography based on microlens technique without any complex equipment and sophisticated controls. Utilizing the convex microlens to focusing UV light for inversed SU-8 lithography, microneedle array can be fabricated in SU-8 form in a simple and direct way. The size and shape of tapered microneedle were basically consistent with the theoretical prediction based on focal length of microlens, satisfying the requirements of microneedles commonly used as well. Poly-lactic-co-glycolic acid (PLGA) microneedle patch replicated from negative polydimethylsiloxane (PDMS) master was successfully applied to mouse skin for penetrating test. It proves that microneedle patch can be produced based on microlens technique and has prospective applications in Transdermal drug delivery (TDD) systems. © 15CBMS-0001.