Increasing avß3 selectivity of the anti-angiogenic drug cilengitide by N-methylation

Authors :: Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
Mas Moruno, Carlos
Beck, J.G.
Doedens, L.
Frank, A.O.
Marinelli, L.
Cosconati, S.
Novellino, E.
Kessler, H.
Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica
Mas Moruno, Carlos
Beck, J.G.
Doedens, L.
Frank, A.O.
Marinelli, L.
Cosconati, S.
Novellino, E.
Kessler, H.
Publication Year :: 2011
Abstract: Thumbnail image of graphical abstract A subtle change: Structural changes upon amide bond methylation improve the selectivity of the anti-angiogenic drug Cilengitide, which after N-methylation at distinct positions discriminates between the closely related pro-angiogenic integrins avß3 and avß5 (see scheme).<br />Peer Reviewed<br />Postprint (published version)

Tools