NAD+ Repletion Rescues Female Fertility during Reproductive Aging

Authors :: Bertoldo, MJ
Listijono, DR
Ho, WHJ
Riepsamen, AH
Goss, DM
Richani, D
Jin, XL
Mahbub, S
Campbell, JM
Habibalahi, A
Loh, WGN
Youngson, NA
Maniam, J
Wong, ASA
Selesniemi, K
Bustamante, S
Li, C
Zhao, Y
Marinova, MB
Kim, LJ
Lau, L
Wu, RM
Mikolaizak, AS
Araki, T
Le Couteur, DG
Turner, N
Morris, MJ
Walters, KA
Goldys, E
O'Neill, C
Gilchrist, RB
Sinclair, DA
Homer, HA
Wu, LE
Bertoldo, MJ
Listijono, DR
Ho, WHJ
Riepsamen, AH
Goss, DM
Richani, D
Jin, XL
Mahbub, S
Campbell, JM
Habibalahi, A
Loh, WGN
Youngson, NA
Maniam, J
Wong, ASA
Selesniemi, K
Bustamante, S
Li, C
Zhao, Y
Marinova, MB
Kim, LJ
Lau, L
Wu, RM
Mikolaizak, AS
Araki, T
Le Couteur, DG
Turner, N
Morris, MJ
Walters, KA
Goldys, E
O'Neill, C
Gilchrist, RB
Sinclair, DA
Homer, HA
Wu, LE
Publication Year :: 2020
Abstract: © 2020 The Author(s) Declining oocyte quality is considered an irreversible feature of aging and is rate limiting for human fertility. Bertoldo et al. show that reversing an age-dependent decline in NAD(P)H restores oocyte quality, embryo development, and functional fertility in aged mice. These findings may be relevant to reproductive medicine.

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