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Shared heritability and functional enrichment across six solid cancers
- Source :
- Jiang , X , Finucane , H K , Schumacher , F R , Schmit , S L , Tyrer , J P , Han , Y , Michailidou , K , Lesseur , C , Kuchenbaecker , K B , Dennis , J , Conti , D V , Casey , G , Gaudet , M M , Huyghe , J R , Albanes , D , Aldrich , M C , Andrew , A S , Andrulis , I L , Anton-Culver , H , Antoniou , A C , Antonenkova , N N , Arnold , S M , Aronson , K J , Arun , B K , Bandera , E V , Barkardottir , R B , Barnes , D R , Batra , J , Beckmann , M W , Benitez , J , Benlloch , S , Berchuck , A , Berndt , S I , Bickeböller , H , Bien , S A , Blomqvist , C , Boccia , S , Bogdanova , N V , Bojesen , S E , Bolla , M K , Brauch , H , Brenner , H , Brenton , J D , Brook , M N , Brunet , J , Brunnström , H , Buchanan , D D , Burwinkel , B , Butzow , R , Cadoni , G , Caldés , T , Caligo , M A , Campbell , I , Campbell , P T , Cancel-Tassin , G , Cannon-Albright , L , Campa , D , Caporaso , N , Carvalho , A L , Chan , A T , Chang-Claude , J , Chanock , S J , Chen , C , Christiani , D C , Claes , K B M , Claessens , F , Clements , J , Collée , J M , Correa , M C , Couch , F J , Cox , A , Cunningham , J M , Cybulski , C , Czene , K , Daly , M B , deFazio , A , Devilee , P , Diez , O , Gago-Dominguez , M , Donovan , J L , Dörk , T , Duell , E J , Dunning , A M , Dwek , M , Eccles , D M , Edlund , C K , Edwards , D R V , Ellberg , C , Evans , D G , Fasching , P A , Ferris , R L , Liloglou , T , Figueiredo , J C , Fletcher , O , Fortner , R T , Fostira , F , Franceschi , S , Friedman , E , Gallinger , S J , Ganz , P A , Garber , J , García-Sáenz , J A , Gayther , S A , Giles , G G , Godwin , A K , Goldberg , M S , Goldgar , D E , Goode , E L , Goodman , M T , Goodman , G , Grankvist , K , Greene , M H , Gronberg , H , Gronwald , J , Guénel , P , Håkansson , N , Hall , P , Hamann , U , Hamdy , F C , Hamilton , R J , Hampe , J , Haugen , A , Heitz , F , Herrero , R , Hillemanns , P , Hoffmeister , M , Høgdall , E , Hong , Y-C , Hopper , J L , Houlston , R , Hulick , P J , Hunter , D J
- Publication Year :
- 2019
-
Abstract
- Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Details
- Database :
- OAIster
- Journal :
- Jiang , X , Finucane , H K , Schumacher , F R , Schmit , S L , Tyrer , J P , Han , Y , Michailidou , K , Lesseur , C , Kuchenbaecker , K B , Dennis , J , Conti , D V , Casey , G , Gaudet , M M , Huyghe , J R , Albanes , D , Aldrich , M C , Andrew , A S , Andrulis , I L , Anton-Culver , H , Antoniou , A C , Antonenkova , N N , Arnold , S M , Aronson , K J , Arun , B K , Bandera , E V , Barkardottir , R B , Barnes , D R , Batra , J , Beckmann , M W , Benitez , J , Benlloch , S , Berchuck , A , Berndt , S I , Bickeböller , H , Bien , S A , Blomqvist , C , Boccia , S , Bogdanova , N V , Bojesen , S E , Bolla , M K , Brauch , H , Brenner , H , Brenton , J D , Brook , M N , Brunet , J , Brunnström , H , Buchanan , D D , Burwinkel , B , Butzow , R , Cadoni , G , Caldés , T , Caligo , M A , Campbell , I , Campbell , P T , Cancel-Tassin , G , Cannon-Albright , L , Campa , D , Caporaso , N , Carvalho , A L , Chan , A T , Chang-Claude , J , Chanock , S J , Chen , C , Christiani , D C , Claes , K B M , Claessens , F , Clements , J , Collée , J M , Correa , M C , Couch , F J , Cox , A , Cunningham , J M , Cybulski , C , Czene , K , Daly , M B , deFazio , A , Devilee , P , Diez , O , Gago-Dominguez , M , Donovan , J L , Dörk , T , Duell , E J , Dunning , A M , Dwek , M , Eccles , D M , Edlund , C K , Edwards , D R V , Ellberg , C , Evans , D G , Fasching , P A , Ferris , R L , Liloglou , T , Figueiredo , J C , Fletcher , O , Fortner , R T , Fostira , F , Franceschi , S , Friedman , E , Gallinger , S J , Ganz , P A , Garber , J , García-Sáenz , J A , Gayther , S A , Giles , G G , Godwin , A K , Goldberg , M S , Goldgar , D E , Goode , E L , Goodman , M T , Goodman , G , Grankvist , K , Greene , M H , Gronberg , H , Gronwald , J , Guénel , P , Håkansson , N , Hall , P , Hamann , U , Hamdy , F C , Hamilton , R J , Hampe , J , Haugen , A , Heitz , F , Herrero , R , Hillemanns , P , Hoffmeister , M , Høgdall , E , Hong , Y-C , Hopper , J L , Houlston , R , Hulick , P J , Hunter , D J
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1153677984
- Document Type :
- Electronic Resource