The therapeutic modalities examination in controlling the radiation mucositis of the postresectional defects of the orofacial region cancer

Introduction: The significance of multi-dimensional influence of maxillofacial tumors brought about an increased interest in patients "Quality of Life". The studies of Quality of Life give clinical information about the disease effects, therapy and undesired effects. The advantages for the patients in these studies are such that they can express their opinion on the negative aspects of the disease and contribute in making therapeutic decisions since the period of outliving is not directly connected with the improvement of QOL. The aim of this study was to research the effects of various therapeutic modalities on radiation mucositis in patients with postresectional defects of orofacial region. Methodology: This study includes 30 patients with orofacial region cancer who were consecutively prosthetically rehabilitated after the surgical threatment and subjected to radiotherapy. The patients were divided into three groups of respondents. By random selection method, one group of respondents had a standard protocol in radiation mucositis therapy representing control group. The second and the third group had preparations Stomatovis and Gelclair along with standard therapy representing experimental groups. BMS questionnaires (0., and control) were used in visual qualification of the patients symptomatology. Evaluation of quality of life data was done by the questionnaire EORTC QLQ C-30 in version 3.0 and its addition QLQ H&N35, in the Serbian language. The questionnaire OHIP20 (The Oral Health Impact Profile) was used in evaluation the Quality of the prosthetic therapy in patients. Both microbiological work of material patterns and identification of isolated kinds of microorganisms were done in the laboratory - department Microbiology and Immunology of the Dentistry School in Belgrade. The treatment meant standard microscopic, cultural and biochemical identification. The identification meant standard bacteriological methods and quantification was done counting sprouted col
Značaj multidimenzionalnog uticaja maksilofacijalnih tumora je doveo do povećanog interesovanja za kvalitet života pacijenata. Studije QOL(Quality of Life) daju kliničke informacije o efektima bolesti, terapiji i neželjenim efektima. Prednosti za pacijenta u ovim studijama su te da mogu da izraze svoje mišljenje o negativnim aspektima bolesti i doprinesu u donošenju terapijskih odluka jer vreme preživljavanja nije direktno povezano sa poboljšanjem „kvaliteta života“. Cilj ovog istraživanja bio je da se ispita efekat različitih terapijskih modaliteta na radijacioni mukozitis u pacijenata sa postresekcionim defektima orofacijalne regije. Metodologija: U ovom istraživanju, je uključeno 30 pacijenata sa tumorima orofacijalne regije koji su posle hirurške terapije protetski rehabilitovani i podvrgnuti zračnoj terapiji.Pacijenti su podeljeni u tri grupe po deset ispitanika. Metodom slučajnog izbora, jednoj grupi ispitanika je dat standarni protokol u terapiji radijacionih mukozitisa, koja će predstavljati kontrolnu grupu. Drugoj i trećoj grupi ispitanika su pored standardne terapije uključeni preparati „Stomatovis“ i „Gelclair“ i predstavljaju eksperimentane grupe. BMS upitnici (0. i kontrolni ) su korišćeni u vizuelnoj kvalifikaciji simptomatologije pacijenta. Procena podataka kvaliteta života je obrađena u upitniku EORTC-QLQ-C30 verzija 3.0 i njegovom dodatku H&N35, na srpskom jeziku. Upitnik OHIP-20 (The Oral Health Impact Profile) je korišćen u proceni kvaliteta protetske terapije pacijenata. Mikrobiološka obrada uzoraka materijala, kao i identifikacija izolovanih vrsta mikroorganizama, vršeni su u laboratoriji predmeta Mikrobiologija i imunologija stomatološkog fakulteta u Beogradu. Postupak je podrazumevao standardnu mikroskopsku, kulturalnu i biohemijsku identifikaciju. Identifikacija je predstavljala standardne bakteriološke metode, a kvantifikacija je obavljana brojanjem izniklih kolonija na zasejanim hranljivim podlogama. Pri tome su rezultati izraženi kao ukupa