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Common variants at 6q22 and 17q21 are associated with intracranial volume

Authors :
Ikram, M. Arfan
Fornage, Myriam
Smith, Albert V.
Seshadri, Sudha
Schmidt, Reinhold
Debette, Stephanie
Vrooman, Henri A.
Sigurdsson, Sigurdur
Ropele, Stefan
Taal, H. Rob
Mook-Kanamori, Dennis O.
Coker, Laura H.
Longstreth, W. T., Jr.
Niessen, Wiro J.
DeStefano, Anita L.
Beiser, Alexa
Zijdenbos, Alex P.
Struchalin, Maksim
Jack, Clifford R., Jr.
Rivadeneira, Fernando
Uitterlinden, Andre G.
Knopman, David S.
Hartikainen, Anna-Liisa
Pennell, Craig E.
Thiering, Elisabeth
Steegers, Eric A. P.
Hakonarson, Hakon
Heinrich, Joachim
Palmer, Lyle J.
Jarvelin, Marjo-Riitta
McCarthy, Mark I.
Grant, Struan F. A.
St Pourcain, Beate
Timpson, Nicholas J.
Smith, George Davey
Sovio, Ulla
Nalls, Mike A.
Au, Rhoda
Hofman, Albert
Gudnason, Haukur
van der Lugt, Aad
Harris, Tamara B.
Meeks, William M.
Vernooij, Meike W.
van Buchem, Mark A.
Catellier, Diane
Jaddoe, Vincent W. V.
Gudnason, Vilmundur
Windham, B. Gwen
Wolf, Philip A.
van Duijn, Cornelia M.
Mosley, Thomas H., Jr.
Schmidt, Helena
Launer, Lenore J.
Breteler, Monique M. B.
DeCarli, Charles
Adair, Linda S.
Ang, Wei
Atalay, Mustafa
vanBeijsterveldt, Toos
Bergen, Nienke
Benke, Kelly
Berry, Diane
Coin, Lachlan
Davis, Oliver S. P.
Elliott, Paul
Flexeder, Claudia
Frayling, Tim
Gaillard, Romy
Groen-Blokhuis, Maria
Goh, Liang-Kee
Haworth, Claire M. A.
Hadley, Dexter
Hedebrand, Johannes
Hinney, Anke
Hirschhorn, Joel N.
Holloway, John W.
Holst, Claus
Hottenga, Jouke Jan
Horikoshi, Momoko
Huikari, Ville
Hypponen, Elina
Kilpelainen, Tuomas O.
Kirin, Mirna
Kowgier, Matthew
Lakka, Hanna-Maaria
Lange, Leslie A.
Lawlor, Debbie A.
Lehtimaki, Terho
Lewin, Alex
Lindgren, Cecilia
Lindi, Virpi
Maggi, Reedik
Marsh, Julie
Middeldorp, Christel
Millwood, Iona
Murray, Jeffrey C.
Nivard, Michel
Nohr, Ellen Aagaard
Ntalla, Ioanna
Oken, Emily
Panoutsopoulou, Kalliope
Pararajasingham, Jennifer
Rodriguez, Alina
Salem, Rany M.
Sebert, Sylvain
Siitonen, Niina
Strachan, David P.
Teo, Yik-Ying
Valcarcel, Beatriz
Willemsen, Gonneke
Zeggini, Eleftheria
Boomsma, Dorret I.
Cooper, Cyrus
Gillman, Matthew
Hocher, Berthold
Lakka, Timo A.
Mohlke, Karen L.
Dedoussis, George V.
Ong, Ken K.
Pearson, Ewan R.
Price, Thomas S.
Power, Chris
Raitakari, Olli T.
Saw, Seang-Mei
Scherag, Andre
Simell, Olli
Sorensen, Thorkild I. A.
Wilson, James F.
Ikram, M. Arfan
Fornage, Myriam
Smith, Albert V.
Seshadri, Sudha
Schmidt, Reinhold
Debette, Stephanie
Vrooman, Henri A.
Sigurdsson, Sigurdur
Ropele, Stefan
Taal, H. Rob
Mook-Kanamori, Dennis O.
Coker, Laura H.
Longstreth, W. T., Jr.
Niessen, Wiro J.
DeStefano, Anita L.
Beiser, Alexa
Zijdenbos, Alex P.
Struchalin, Maksim
Jack, Clifford R., Jr.
Rivadeneira, Fernando
Uitterlinden, Andre G.
Knopman, David S.
Hartikainen, Anna-Liisa
Pennell, Craig E.
Thiering, Elisabeth
Steegers, Eric A. P.
Hakonarson, Hakon
Heinrich, Joachim
Palmer, Lyle J.
Jarvelin, Marjo-Riitta
McCarthy, Mark I.
Grant, Struan F. A.
St Pourcain, Beate
Timpson, Nicholas J.
Smith, George Davey
Sovio, Ulla
Nalls, Mike A.
Au, Rhoda
Hofman, Albert
Gudnason, Haukur
van der Lugt, Aad
Harris, Tamara B.
Meeks, William M.
Vernooij, Meike W.
van Buchem, Mark A.
Catellier, Diane
Jaddoe, Vincent W. V.
Gudnason, Vilmundur
Windham, B. Gwen
Wolf, Philip A.
van Duijn, Cornelia M.
Mosley, Thomas H., Jr.
Schmidt, Helena
Launer, Lenore J.
Breteler, Monique M. B.
DeCarli, Charles
Adair, Linda S.
Ang, Wei
Atalay, Mustafa
vanBeijsterveldt, Toos
Bergen, Nienke
Benke, Kelly
Berry, Diane
Coin, Lachlan
Davis, Oliver S. P.
Elliott, Paul
Flexeder, Claudia
Frayling, Tim
Gaillard, Romy
Groen-Blokhuis, Maria
Goh, Liang-Kee
Haworth, Claire M. A.
Hadley, Dexter
Hedebrand, Johannes
Hinney, Anke
Hirschhorn, Joel N.
Holloway, John W.
Holst, Claus
Hottenga, Jouke Jan
Horikoshi, Momoko
Huikari, Ville
Hypponen, Elina
Kilpelainen, Tuomas O.
Kirin, Mirna
Kowgier, Matthew
Lakka, Hanna-Maaria
Lange, Leslie A.
Lawlor, Debbie A.
Lehtimaki, Terho
Lewin, Alex
Lindgren, Cecilia
Lindi, Virpi
Maggi, Reedik
Marsh, Julie
Middeldorp, Christel
Millwood, Iona
Murray, Jeffrey C.
Nivard, Michel
Nohr, Ellen Aagaard
Ntalla, Ioanna
Oken, Emily
Panoutsopoulou, Kalliope
Pararajasingham, Jennifer
Rodriguez, Alina
Salem, Rany M.
Sebert, Sylvain
Siitonen, Niina
Strachan, David P.
Teo, Yik-Ying
Valcarcel, Beatriz
Willemsen, Gonneke
Zeggini, Eleftheria
Boomsma, Dorret I.
Cooper, Cyrus
Gillman, Matthew
Hocher, Berthold
Lakka, Timo A.
Mohlke, Karen L.
Dedoussis, George V.
Ong, Ken K.
Pearson, Ewan R.
Price, Thomas S.
Power, Chris
Raitakari, Olli T.
Saw, Seang-Mei
Scherag, Andre
Simell, Olli
Sorensen, Thorkild I. A.
Wilson, James F.
Publication Year :
2012

Abstract

During aging, intracranial volume remains unchanged and represents maximally attained brain size, while various interacting biological phenomena lead to brain volume loss. Consequently, intracranial volume and brain volume in late life reflect different genetic influences. Our genome-wide association study (GWAS) in 8,175 community-dwelling elderly persons did not reveal any associations at genome-wide significance (P < 5 x 10(-8)) for brain volume. In contrast, intracranial volume was significantly associated with two loci: rs4273712 (P = 3.4 x 10(-11)), a known height-associated locus on chromosome 6q22, and rs9915547 (P = 1.5 x 10(-12)), localized to the inversion on chromosome 17q21. We replicated the associations of these loci with intracranial volume in a separate sample of 1,752 elderly persons (P = 1.1 x 10(-3) for 6q22 and 1.2 x 10(-3) for 17q21). Furthermore, we also found suggestive associations of the 17q21 locus with head circumference in 10,768 children (mean age of 14.5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size.<br />Erratum published in Nature Genetics 2012 Vol 44 no 6 p732.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1233655121
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.ng.2245