Skip to search
Skip to main content
Back to Search
Start Over
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Authors :
Kilpelainen, Tuomas O. Bentley, Amy R. Noordam, Raymond Sung, Yun Ju Schwander, Karen Winkler, Thomas W. Jakupovic, Hermina Chasman, Daniel I. Manning, Alisa Ntalla, Ioanna Aschard, Hugues Brown, Michael R. de las Fuentes, Lisa Franceschini, Nora Guo, Xiuqing Vojinovic, Dina Aslibekyan, Stella Feitosa, Mary F. Kho, Minjung Musani, Solomon K. Richard, Melissa Wang, Heming Wang, Zhe Bartz, Traci M. Bielak, Lawrence F. Campbell, Archie Dorajoo, Rajkumar Fisher, Virginia Hartwig, Fernando P. Horimoto, Andrea R. V. R. Li, Changwei Lohman, Kurt K. Marten, Jonathan Sim, Xueling Smith, Albert V. Tajuddin, Salman M. Alver, Maris Amini, Marzyeh Boissel, Mathilde Chai, Jin Fang Chen, Xu Divers, Jasmin Evangelou, Evangelos Gao, Chuan Graff, Mariaelisa Harris, Sarah E. He, Meian Hsu, Fang-Chi Jackson, Anne U. Zhao, Jing Hua Kraja, Aldi T. Kuehnel, Brigitte Laguzzi, Federica Lyytikainen, Leo-Pekka Nolte, Ilja M. Rauramaa, Rainer Riaz, Muhammad Robino, Antonietta Rueedi, Rico Stringham, Heather M. Takeuchi, Fumihiko van der Most, Peter J. Varga, Tibor V. Verweij, Niek Ware, Erin B. Wen, Wanqing Li, Xiaoyin Yanek, Lisa R. Amin, Najaf Arnett, Donna K. Boerwinkle, Eric Brumat, Marco Cade, Brian Canouil, Mickael Chen, Yii-Der Ida Concas, Maria Pina Connell, John de Mutsert, Renee de Silva, H. Janaka de Vries, Paul S. Demirkan, Ayse Ding, Jingzhong Eaton, Charles B. Faul, Jessica D. Friedlander, Yechiel Gabriel, Kelley P. Ghanbari, Mohsen Giulianini, Franco Gu, Chi Charles Gu, Dongfeng Harris, Tamara B. He, Jiang Heikkinen, Sami Heng, Chew-Kiat Hunt, Steven C. Ikram, M. Arfan Jonas, Jost B. Koh, Woon-Puay Komulainen, Pirjo Krieger, Jose E. Kritchevsky, Stephen B. Kutalik, Zoltan Kuusisto, Johanna Langefeld, Carl D. Langenberg, Claudia Launer, Lenore J. Leander, Karin Lemaitre, Rozenn N. Lewis, Cora E. Liang, Jingjing Alizadeh, Behrooz Z. Boezen, H. Marike Franke, Lude Navis, Gerjan Rots, Marianne Swertz, Morris Wolffenbuttel, Bruce H. R. Wijmenga, Cisca Liu, Jianjun Magi, Reedik Manichaikul, Ani Meitinger, Thomas Metspalu, Andres Milaneschi, Yuri Mohlke, Karen L. Mosley, Thomas H., Jr. Murray, Alison D. Nalls, Mike A. Nang, Ei-Ei Khaing Nelson, Christopher P. Nona, Sotoodehnia Norris, Jill M. Nwuba, Chiamaka Vivian O'Connell, Jeff Palmer, Nicholette D. Papanicolau, George J. Pazoki, Raha Pedersen, Nancy L. Peters, Annette Peyser, Patricia A. Polasek, Ozren Porteous, David J. Poveda, Alaitz Raitakari, Olli T. Rich, Stephen S. Risch, Neil Robinson, Jennifer G. Rose, Lynda M. Rudan, Igor Schreiner, Pamela J. Scott, Robert A. Sidney, Stephen S. Sims, Mario Smith, Jennifer A. Snieder, Harold Sofer, Tamar Starr, John M. Sternfeld, Barbara Strauch, Konstantin Tang, Hua Taylor, Kent D. Tsai, Michael Y. Tuomilehto, Jaakko Uitterlinden, Andre G. van der Ende, M. Yldau van Heemst, Diana Voortman, Trudy Waldenberger, Melanie Wennberg, Patrik Wilson, Gregory Xiang, Yong-Bing Yao, Jie Yu, Caizheng Yuan, Jian-Min Zhao, Wei Zonderman, Alan B. Becker, Diane M. Boehnke, Michael Bowden, Donald W. de Faire, Ulf Deary, Ian J. Elliott, Paul Esko, Tonu Freedman, Barry I. Froguel, Philippe Gasparini, Paolo Gieger, Christian Kato, Norihiro Laakso, Markku Lakka, Timo A. Lehtimaaki, Terho Magnusson, Patrik K. E. Oldehinkel, Albertine J. Penninx, Brenda W. J. H. Samani, Nilesh J. Shu, Xiao-Ou van der Harst, Pim Van Vliet-Ostaptchouk, Jana V. Vollenweider, Peter Wagenknecht, Lynne E. Wang, Ya X. Wareham, Nicholas J. Weir, David R. Wu, Tangchun Zheng, Wei Zhu, Xiaofeng Evans, Michele K. Franks, Paul W. Gudnason, Vilmundur Hayward, Caroline Horta, Bernardo L. Kelly, Tanika N. Liu, Yongmei North, Kari E. Pereira, Alexandre C. Ridker, Paul M. Tai, E. Shyong van Dam, Rob M. Fox, Ervin R. Kardia, Sharon L. R. Liu, Ching-Ti Mook-Kanamori, Dennis O. Province, Michael A. Redline, Susan van Duijn, Cornelia M. Rotter, Jerome I. Kooperberg, Charles B. Gauderman, W. James Psaty, Bruce M. Rice, Kenneth Munroe, Patricia B. Fornage, Myriam Cupples, L. Adrienne Rotimi, Charles N. Morrison, Alanna C. Rao, Dabeeru C. Loos, Ruth J. F. Kilpelainen, Tuomas O. Bentley, Amy R. Noordam, Raymond Sung, Yun Ju Schwander, Karen Winkler, Thomas W. Jakupovic, Hermina Chasman, Daniel I. Manning, Alisa Ntalla, Ioanna Aschard, Hugues Brown, Michael R. de las Fuentes, Lisa Franceschini, Nora Guo, Xiuqing Vojinovic, Dina Aslibekyan, Stella Feitosa, Mary F. Kho, Minjung Musani, Solomon K. Richard, Melissa Wang, Heming Wang, Zhe Bartz, Traci M. Bielak, Lawrence F. Campbell, Archie Dorajoo, Rajkumar Fisher, Virginia Hartwig, Fernando P. Horimoto, Andrea R. V. R. Li, Changwei Lohman, Kurt K. Marten, Jonathan Sim, Xueling Smith, Albert V. Tajuddin, Salman M. Alver, Maris Amini, Marzyeh Boissel, Mathilde Chai, Jin Fang Chen, Xu Divers, Jasmin Evangelou, Evangelos Gao, Chuan Graff, Mariaelisa Harris, Sarah E. He, Meian Hsu, Fang-Chi Jackson, Anne U. Zhao, Jing Hua Kraja, Aldi T. Kuehnel, Brigitte Laguzzi, Federica Lyytikainen, Leo-Pekka Nolte, Ilja M. Rauramaa, Rainer Riaz, Muhammad Robino, Antonietta Rueedi, Rico Stringham, Heather M. Takeuchi, Fumihiko van der Most, Peter J. Varga, Tibor V. Verweij, Niek Ware, Erin B. Wen, Wanqing Li, Xiaoyin Yanek, Lisa R. Amin, Najaf Arnett, Donna K. Boerwinkle, Eric Brumat, Marco Cade, Brian Canouil, Mickael Chen, Yii-Der Ida Concas, Maria Pina Connell, John de Mutsert, Renee de Silva, H. Janaka de Vries, Paul S. Demirkan, Ayse Ding, Jingzhong Eaton, Charles B. Faul, Jessica D. Friedlander, Yechiel Gabriel, Kelley P. Ghanbari, Mohsen Giulianini, Franco Gu, Chi Charles Gu, Dongfeng Harris, Tamara B. He, Jiang Heikkinen, Sami Heng, Chew-Kiat Hunt, Steven C. Ikram, M. Arfan Jonas, Jost B. Koh, Woon-Puay Komulainen, Pirjo Krieger, Jose E. Kritchevsky, Stephen B. Kutalik, Zoltan Kuusisto, Johanna Langefeld, Carl D. Langenberg, Claudia Launer, Lenore J. Leander, Karin Lemaitre, Rozenn N. Lewis, Cora E. Liang, Jingjing Alizadeh, Behrooz Z. Boezen, H. Marike Franke, Lude Navis, Gerjan Rots, Marianne Swertz, Morris Wolffenbuttel, Bruce H. R. Wijmenga, Cisca Liu, Jianjun Magi, Reedik Manichaikul, Ani Meitinger, Thomas Metspalu, Andres Milaneschi, Yuri Mohlke, Karen L. Mosley, Thomas H., Jr. Murray, Alison D. Nalls, Mike A. Nang, Ei-Ei Khaing Nelson, Christopher P. Nona, Sotoodehnia Norris, Jill M. Nwuba, Chiamaka Vivian O'Connell, Jeff Palmer, Nicholette D. Papanicolau, George J. Pazoki, Raha Pedersen, Nancy L. Peters, Annette Peyser, Patricia A. Polasek, Ozren Porteous, David J. Poveda, Alaitz Raitakari, Olli T. Rich, Stephen S. Risch, Neil Robinson, Jennifer G. Rose, Lynda M. Rudan, Igor Schreiner, Pamela J. Scott, Robert A. Sidney, Stephen S. Sims, Mario Smith, Jennifer A. Snieder, Harold Sofer, Tamar Starr, John M. Sternfeld, Barbara Strauch, Konstantin Tang, Hua Taylor, Kent D. Tsai, Michael Y. Tuomilehto, Jaakko Uitterlinden, Andre G. van der Ende, M. Yldau van Heemst, Diana Voortman, Trudy Waldenberger, Melanie Wennberg, Patrik Wilson, Gregory Xiang, Yong-Bing Yao, Jie Yu, Caizheng Yuan, Jian-Min Zhao, Wei Zonderman, Alan B. Becker, Diane M. Boehnke, Michael Bowden, Donald W. de Faire, Ulf Deary, Ian J. Elliott, Paul Esko, Tonu Freedman, Barry I. Froguel, Philippe Gasparini, Paolo Gieger, Christian Kato, Norihiro Laakso, Markku Lakka, Timo A. Lehtimaaki, Terho Magnusson, Patrik K. E. Oldehinkel, Albertine J. Penninx, Brenda W. J. H. Samani, Nilesh J. Shu, Xiao-Ou van der Harst, Pim Van Vliet-Ostaptchouk, Jana V. Vollenweider, Peter Wagenknecht, Lynne E. Wang, Ya X. Wareham, Nicholas J. Weir, David R. Wu, Tangchun Zheng, Wei Zhu, Xiaofeng Evans, Michele K. Franks, Paul W. Gudnason, Vilmundur Hayward, Caroline Horta, Bernardo L. Kelly, Tanika N. Liu, Yongmei North, Kari E. Pereira, Alexandre C. Ridker, Paul M. Tai, E. Shyong van Dam, Rob M. Fox, Ervin R. Kardia, Sharon L. R. Liu, Ching-Ti Mook-Kanamori, Dennis O. Province, Michael A. Redline, Susan van Duijn, Cornelia M. Rotter, Jerome I. Kooperberg, Charles B. Gauderman, W. James Psaty, Bruce M. Rice, Kenneth Munroe, Patricia B. Fornage, Myriam Cupples, L. Adrienne Rotimi, Charles N. Morrison, Alanna C. Rao, Dabeeru C. Loos, Ruth J. F.
Publication Year :
2019
Abstract
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol- increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
Details
Database :
OAIster
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1234579274
Document Type :
Electronic Resource
Full Text :
https://doi.org/10.1038.s41467-018-08008-w