Evolutionary design of glutathione-linked proteins in vivo and in vitro based on sampling of modules from pre-existing structures

Authors :: Mannervik, B
Bolton-Grob, R
Cameron, AD
Etahadieh, M
Gustafsson, A
Hansson, LO
Hubatsch, I
Jemth, P
Johansson, AS
Jones, TA
Larsson, AK
Nilsson, LO
Olin, B
Pettersson, PL
Ridderstrom, M
Stenberg, G
Widersten, M
Wisen, S
Mannervik, B
Bolton-Grob, R
Cameron, AD
Etahadieh, M
Gustafsson, A
Hansson, LO
Hubatsch, I
Jemth, P
Johansson, AS
Jones, TA
Larsson, AK
Nilsson, LO
Olin, B
Pettersson, PL
Ridderstrom, M
Stenberg, G
Widersten, M
Wisen, S
Publication Year :: 2001
Abstract: Structural studies suggest that naturally occurring proteins represent a limited number of folds. It would appear that the evolution of novel protein functions to a large extent involves redesign of stable peptide scaffolds by means of combinatorial prote<br />Addresses: Mannervik B, Uppsala Univ, Dept Biochem, Ctr Biomed, Box 576, SE-75123 Uppsala, Sweden. Uppsala Univ, Dept Biochem, Ctr Biomed, SE-75123 Uppsala, Sweden. Uppsala Univ, Dept Mol Biol, SE-75123 Uppsala, Sweden.

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