Skip to search
Skip to main content
Back to Search
Start Over
Identification of six new susceptibility loci for invasive epithelial ovarian cancer
Authors :
Kuchenbaecker, Karoline B. Ramus, Susan J. Tyrer, Jonathan Lee, Andrew Shen, Howard C. Beesley, Jonathan Lawrenson, Kate McGuffog, Lesley Healey, Sue Lee, Janet M. Spindler, Tassja J. Lin, Yvonne G. Pejovic, Tanja Bean, Yukie Li, Qiyuan Coetzee, Simon Hazelett, Dennis Miron, Alexander Southey, Melissa Terry, Mary Beth Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Neuhausen, Susan L. Ding, Yuan Chun Hansen, Thomas V. O. Jonson, Lars Gerdes, Anne-Marie Ejlertsen, Bent Barrowdale, Daniel Dennis, Joe Benitez, Javier Osorio, Ana Garcia, Maria Jose Komenaka, Ian Weitzel, Jeffrey N. Ganschow, Pamela Peterlongo, Paolo Bernard, Loris Viel, Alessandra Bonanni, Bernardo Peissel, Bernard Manoukian, Siranoush Radice, Paolo Papi, Laura Ottini, Laura Fostira, Florentia Konstantopoulou, Irene Garber, Judy Frost, Debra Perkins, Jo Platte, Radka Ellis, Steve Godwin, Andrew K. Schmutzler, Rita Katharina Meindl, Alfons Engel, Christoph Sutter, Christian Sinilnikova, Olga M. Damiola, Francesca Mazoyer, Sylvie Stoppa-Lyonnet, Dominique Claes, Kathleen De Leeneer, Kim Kirk, Judy Rodriguez, Gustavo C. Piedmonte, Marion O'Malley, David M. de la Hoya, Miguel Caldes, Trinidad Aittomaeki, Kristiina Nevanlinna, Heli Collee, J. Margriet Rookus, Matti A. Oosterwijk, Jan C. Tihomirova, Laima Tung, Nadine Hamann, Ute Isaccs, Claudine Tischkowitz, Marc Imyanitov, Evgeny N. Caligo, Maria A. Campbell, Ian G. Hogervorst, Frans B. L. Olah, Edith Diez, Orland Blanco, Ignacio Brunet, Joan Lazaroso, Conxi Angel Pujana, Miguel Jakubowska, Anna Gronwald, Jacek Lubinski, Jan Sukiennicki, Grzegorz Barkardottir, Rosa B. Plante, Marie Simard, Jacques Soucy, Penny Montagna, Marco Tognazzo, Silvia Teixeira, Manuel R. Pankratz, Vernon S. Wang, Xianshu Lindor, Noralane Szabo, Csilla I. Kauff, Noah Vijai, Joseph Aghajanian, Carol A. Pfeiler, Georg Berger, Andreas Singer, Christian F. Tea, Muy-Kheng Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Tchatchou, Sandrine Andrulis, Irene L. Glendon, Gord Toland, Amanda Ewart Jensen, Uffe Birk Kruse, Torben A. Thomassen, Mads Bojesen, Anders Zidan, Jamal Friedman, Eitan Laitman, Yael Soller, Maria Liljegren, Annelie Arver, Brita Einbeigi, Zakaria Stenmark-Askmalm, Marie Olopade, Olufunmilayo I. Nussbaum, Robert L. Rebbeck, Timothy R. Nathanson, Katherine L. Domchek, Susan M. Lu, Karen H. Karlan, Beth Y. Walsh, Christine Lester, Jenny Hein, Alexander Ekici, Arif B. Beckmann, Matthias W. Fasching, Peter A. Lambrechts, Diether Van Nieuwenhuysen, Els Vergote, Ignace Lambrechts, Sandrina Dicks, Ed Doherty, Jennifer A. Wicklund, Kristine G. Rossing, Mary Anne Rudolph, Anja Chang-Claude, Jenny Wang-Gohrke, Shan Eilber, Ursula Moysich, Kirsten B. Odunsi, Kunle Sucheston, Lara Lele, Shashi Wilkens, Lynne R. Goodman, Marc T. Thompson, Pamela J. Shvetsov, Yurii B. Runnebaum, Ingo B. Duerst, Matthias Hillemanns, Peter Doerk, Thilo Antonenkova, Natalia Bogdanova, Natalia Leminen, Arto Pelttari, Liisa M. Butzow, Ralf Modugno, Francesmary Kelley, Joseph L. Edwards, Robert P. Ness, Roberta B. du Bois, Andreas Heitz, Florian Schwaab, Ira Harter, Philipp Matsuo, Keitaro Hosono, Satoyo Orsulic, Sandra Jensen, Allan Kjaer, Susanne Kruger Hogdall, Estrid Hasmad, Hanis Nazihah Azmi, Mat Adenan Noor Teo, Soo-Hwang Woo, Yin-Ling Fridley, Brooke L. Goode, Ellen L. Cunningham, Julie M. Vierkant, Robert A. Bruinsma, Fiona Giles, Graham G. Liang, Dong Hildebrandt, Michelle A. T. Wu, Xifeng Levine, Douglas A. Bisogna, Maria Berchuck, Andrew Iversen, Edwin S. Schildkraut, Joellen M. Concannon, Patrick Weber, Rachel Palmieri Cramer, Daniel W. Terry, Kathryn L. Poole, Elizabeth M. Tworoger, Shelley S. Bandera, Elisa V. Orlow, Irene Olson, Sara H. Krakstad, Camilla Salvesen, Helga B. Tangen, Ingvild L. Bjorge, Line van Altena, Anne M. Aben, Katja K. H. Kiemeney, Lambertus A. Massuger, Leon F. A. G. Kellar, Melissa Brooks-Wilson, Angela Kelemen, Linda E. Cook, Linda S. Le, Nhu D. Cybulski, Cezary Yang, Hannah Lissowska, Jolanta Brinton, Louise A. Wentzensen, Nicolas Hogdall, Claus Lundvall, Lene Nedergaard, Lotte Baker, Helen Song, Honglin Eccles, Diana McNeish, Ian Paul, James Carty, Karen Siddiqui, Nadeem Glasspool, Rosalind Whittemore, Alice S. Rothstein, Joseph H. McGuire, Valerie Sieh, Weiva Ji, Bu-Tian Zheng, Wei Shu, Xiao-Ou Gao, Yu-Tang Rosen, Barry Risch, Harvey A. McLaughlin, John R. Narod, Steven A. Monteiro, Alvaro N. Chen, Ann Lin, Hui-Yi Permuth-Wey, Jenny Sellers, Thomas A. Tsai, Ya-Yu Chen, Zhihua Ziogas, Argyrios Anton-Culver, Hoda Gentry-Maharaj, Aleksandra Menon, Usha Harrington, Patricia Lee, Alice W. Wu, Anna H. Pearce, Celeste L. Coetzee, Gerry Pike, Malcolm C. Dansonka-Mieszkowska, Agnieszka Timorek, Agnieszka Rzepecka, Iwona K. Kupryjanczyk, Jolanta Freedman, Matt Noushmehr, Houtan Easton, Douglas F. Offit, Kenneth Couch, Fergus J. Gayther, Simon Pharoah, Paul P. Antoniou, Antonis C. Chenevix-Trench, Georgia Kuchenbaecker, Karoline B. Ramus, Susan J. Tyrer, Jonathan Lee, Andrew Shen, Howard C. Beesley, Jonathan Lawrenson, Kate McGuffog, Lesley Healey, Sue Lee, Janet M. Spindler, Tassja J. Lin, Yvonne G. Pejovic, Tanja Bean, Yukie Li, Qiyuan Coetzee, Simon Hazelett, Dennis Miron, Alexander Southey, Melissa Terry, Mary Beth Goldgar, David E. Buys, Saundra S. Janavicius, Ramunas Dorfling, Cecilia M. van Rensburg, Elizabeth J. Neuhausen, Susan L. Ding, Yuan Chun Hansen, Thomas V. O. Jonson, Lars Gerdes, Anne-Marie Ejlertsen, Bent Barrowdale, Daniel Dennis, Joe Benitez, Javier Osorio, Ana Garcia, Maria Jose Komenaka, Ian Weitzel, Jeffrey N. Ganschow, Pamela Peterlongo, Paolo Bernard, Loris Viel, Alessandra Bonanni, Bernardo Peissel, Bernard Manoukian, Siranoush Radice, Paolo Papi, Laura Ottini, Laura Fostira, Florentia Konstantopoulou, Irene Garber, Judy Frost, Debra Perkins, Jo Platte, Radka Ellis, Steve Godwin, Andrew K. Schmutzler, Rita Katharina Meindl, Alfons Engel, Christoph Sutter, Christian Sinilnikova, Olga M. Damiola, Francesca Mazoyer, Sylvie Stoppa-Lyonnet, Dominique Claes, Kathleen De Leeneer, Kim Kirk, Judy Rodriguez, Gustavo C. Piedmonte, Marion O'Malley, David M. de la Hoya, Miguel Caldes, Trinidad Aittomaeki, Kristiina Nevanlinna, Heli Collee, J. Margriet Rookus, Matti A. Oosterwijk, Jan C. Tihomirova, Laima Tung, Nadine Hamann, Ute Isaccs, Claudine Tischkowitz, Marc Imyanitov, Evgeny N. Caligo, Maria A. Campbell, Ian G. Hogervorst, Frans B. L. Olah, Edith Diez, Orland Blanco, Ignacio Brunet, Joan Lazaroso, Conxi Angel Pujana, Miguel Jakubowska, Anna Gronwald, Jacek Lubinski, Jan Sukiennicki, Grzegorz Barkardottir, Rosa B. Plante, Marie Simard, Jacques Soucy, Penny Montagna, Marco Tognazzo, Silvia Teixeira, Manuel R. Pankratz, Vernon S. Wang, Xianshu Lindor, Noralane Szabo, Csilla I. Kauff, Noah Vijai, Joseph Aghajanian, Carol A. Pfeiler, Georg Berger, Andreas Singer, Christian F. Tea, Muy-Kheng Phelan, Catherine M. Greene, Mark H. Mai, Phuong L. Rennert, Gad Mulligan, Anna Marie Tchatchou, Sandrine Andrulis, Irene L. Glendon, Gord Toland, Amanda Ewart Jensen, Uffe Birk Kruse, Torben A. Thomassen, Mads Bojesen, Anders Zidan, Jamal Friedman, Eitan Laitman, Yael Soller, Maria Liljegren, Annelie Arver, Brita Einbeigi, Zakaria Stenmark-Askmalm, Marie Olopade, Olufunmilayo I. Nussbaum, Robert L. Rebbeck, Timothy R. Nathanson, Katherine L. Domchek, Susan M. Lu, Karen H. Karlan, Beth Y. Walsh, Christine Lester, Jenny Hein, Alexander Ekici, Arif B. Beckmann, Matthias W. Fasching, Peter A. Lambrechts, Diether Van Nieuwenhuysen, Els Vergote, Ignace Lambrechts, Sandrina Dicks, Ed Doherty, Jennifer A. Wicklund, Kristine G. Rossing, Mary Anne Rudolph, Anja Chang-Claude, Jenny Wang-Gohrke, Shan Eilber, Ursula Moysich, Kirsten B. Odunsi, Kunle Sucheston, Lara Lele, Shashi Wilkens, Lynne R. Goodman, Marc T. Thompson, Pamela J. Shvetsov, Yurii B. Runnebaum, Ingo B. Duerst, Matthias Hillemanns, Peter Doerk, Thilo Antonenkova, Natalia Bogdanova, Natalia Leminen, Arto Pelttari, Liisa M. Butzow, Ralf Modugno, Francesmary Kelley, Joseph L. Edwards, Robert P. Ness, Roberta B. du Bois, Andreas Heitz, Florian Schwaab, Ira Harter, Philipp Matsuo, Keitaro Hosono, Satoyo Orsulic, Sandra Jensen, Allan Kjaer, Susanne Kruger Hogdall, Estrid Hasmad, Hanis Nazihah Azmi, Mat Adenan Noor Teo, Soo-Hwang Woo, Yin-Ling Fridley, Brooke L. Goode, Ellen L. Cunningham, Julie M. Vierkant, Robert A. Bruinsma, Fiona Giles, Graham G. Liang, Dong Hildebrandt, Michelle A. T. Wu, Xifeng Levine, Douglas A. Bisogna, Maria Berchuck, Andrew Iversen, Edwin S. Schildkraut, Joellen M. Concannon, Patrick Weber, Rachel Palmieri Cramer, Daniel W. Terry, Kathryn L. Poole, Elizabeth M. Tworoger, Shelley S. Bandera, Elisa V. Orlow, Irene Olson, Sara H. Krakstad, Camilla Salvesen, Helga B. Tangen, Ingvild L. Bjorge, Line van Altena, Anne M. Aben, Katja K. H. Kiemeney, Lambertus A. Massuger, Leon F. A. G. Kellar, Melissa Brooks-Wilson, Angela Kelemen, Linda E. Cook, Linda S. Le, Nhu D. Cybulski, Cezary Yang, Hannah Lissowska, Jolanta Brinton, Louise A. Wentzensen, Nicolas Hogdall, Claus Lundvall, Lene Nedergaard, Lotte Baker, Helen Song, Honglin Eccles, Diana McNeish, Ian Paul, James Carty, Karen Siddiqui, Nadeem Glasspool, Rosalind Whittemore, Alice S. Rothstein, Joseph H. McGuire, Valerie Sieh, Weiva Ji, Bu-Tian Zheng, Wei Shu, Xiao-Ou Gao, Yu-Tang Rosen, Barry Risch, Harvey A. McLaughlin, John R. Narod, Steven A. Monteiro, Alvaro N. Chen, Ann Lin, Hui-Yi Permuth-Wey, Jenny Sellers, Thomas A. Tsai, Ya-Yu Chen, Zhihua Ziogas, Argyrios Anton-Culver, Hoda Gentry-Maharaj, Aleksandra Menon, Usha Harrington, Patricia Lee, Alice W. Wu, Anna H. Pearce, Celeste L. Coetzee, Gerry Pike, Malcolm C. Dansonka-Mieszkowska, Agnieszka Timorek, Agnieszka Rzepecka, Iwona K. Kupryjanczyk, Jolanta Freedman, Matt Noushmehr, Houtan Easton, Douglas F. Offit, Kenneth Couch, Fergus J. Gayther, Simon Pharoah, Paul P. Antoniou, Antonis C. Chenevix-Trench, Georgia
Publication Year :
2015
Abstract
Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 x 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers.
Details
Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1247373606
Document Type :
Electronic Resource