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Cytokine induced killer cells-assisted delivery of chlorin e6 mediated self-assembled gold nanoclusters to tumors for imaging and immuno-photodynamic therapy

Authors :
National Natural Science Foundation of China
China Postdoctoral Science Foundation
National Basic Research Program (China)
Shanghai Science and Technology Committee
Xia, Fangfang
Hou, Wenxiu
Liu, Yanlei
Wang, Wentao
Han, Yu
Yang, Meng
Zhi, Xiao
Li, Chenlu
Qi, Daizong
Li, Tianliang
Fuente, Jesús M. de la
Zhang, Chunlei
Song, Jie
Cui, Daxiang
National Natural Science Foundation of China
China Postdoctoral Science Foundation
National Basic Research Program (China)
Shanghai Science and Technology Committee
Xia, Fangfang
Hou, Wenxiu
Liu, Yanlei
Wang, Wentao
Han, Yu
Yang, Meng
Zhi, Xiao
Li, Chenlu
Qi, Daizong
Li, Tianliang
Fuente, Jesús M. de la
Zhang, Chunlei
Song, Jie
Cui, Daxiang
Publication Year :
2018

Abstract

The cytotoxicity and unique tumor-tropic properties of cytokine-induced killer (CIK) cells render them promising in the field of cancer immunotherapy and delivery systems. Here, we report a novel and facile approach to assemble gold nanoclusters (GNCs) into stable and monodispersed nanoparticles (NPs) using Chlorin e6 (Ce6) molecules. Notably, the fluorescence intensity of the GNCs-Ce6 NPs was about 4.5 folds stronger than the GNCs counterparts. The as-prepared GNCs-Ce6 NPs were conjugated with CD3 antibody (Ab) and further employed to label CIK cells to create a CIK cell-based drug delivery system (Ce6-GNCs-Ab-CIK). The Ce6-GNCs-Ab-CIK exhibited high tumor-targeting efficiency and excellent therapeutic efficacy toward MGC-803 tumor-bearing mice. Benefiting from the synergistic therapeutic effect between GNCs-Ce6-Ab NPs and CIK cells, the GNCs-Ce6-Ab-CIK strategy may present an ideal cancer theranostic platform for tumor targeted imaging and combination therapy.

Details

Database :
OAIster
Notes :
English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1257717753
Document Type :
Electronic Resource