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Elastomeric cardiopatch scaffold for myocardial repair and ventricular support

Authors :
Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada
European Regional Development Fund
European Commission
Chachques, Juan Carlos
Lila, Nermine
Soler Botija, Carolina
Martínez-Ramos, Cristina
Vallés Lluch, Ana
Autret, Gwennhael
Perier, Marie-Cecile
Mirochnik, Nicolas
Monleón Pradas, Manuel
Bayes-Genis, Antoni
Semino, Carlos E.
Universitat Politècnica de València. Departamento de Termodinámica Aplicada - Departament de Termodinàmica Aplicada
European Regional Development Fund
European Commission
Chachques, Juan Carlos
Lila, Nermine
Soler Botija, Carolina
Martínez-Ramos, Cristina
Vallés Lluch, Ana
Autret, Gwennhael
Perier, Marie-Cecile
Mirochnik, Nicolas
Monleón Pradas, Manuel
Bayes-Genis, Antoni
Semino, Carlos E.
Publication Year :
2020

Abstract

[EN] OBJECTIVES: Prevention of postischaemic ventricular dilatation progressing towards pathological remodelling is necessary to decrease ventricular wall deterioration. Myocardial tissue engineering may play a therapeutic role due to its capacity to replace the extracellular matrix, thereby creating niches for cell homing. In this experimental animal study, a biomimetic cardiopatch was created with elastomeric scaffolds and nanotechnologies. METHODS: In an experimental animal study in 18 sheep, a cardiopatch was created with adipose tissue-derived progenitor cells seeded into an engineered bioimplant consisting of 3-dimensional bioabsorbable polycaprolactone scaffolds filled with a peptide hydrogel (PuraMatrix (TM)). This patch was then transplanted to cover infarcted myocardium. Non-absorbable poly(ethyl) acrylate polymer scaffolds were used as controls. RESULTS: Fifteen sheep were followed with ultrasound scans at 6 months, including echocardiography scans, tissue Doppler and spectral flow analysis and speckle-tracking imaging, which showed a reduction in longitudinal left ventricular deformation in the cardiopatch-treated group. Magnetic resonance imaging (late gadolinium enhancement) showed reduction of infarct size relative to left ventricular mass in the cardiopatch group versus the controls. Histopathological analysis at 6 months showed that the cardiopatch was fully anchored and integrated to the infarct area with minimal fibrosis interface, thereby promoting angiogenesis and migration of adipose tissue-derived progenitor cells to surrounding tissues. CONCLUSIONS: This study shows the feasibility and effectiveness of a cardiopatch grafted onto myocardial infarction scars in an experimental animal model. This treatment decreased fibrosis, limited infarct scar expansion and reduced postischaemic ventricular deformity. A capillary network developed between our scaffold and the heart. The elastomeric cardiopatch seems to have a positive impact on ventricular re

Details

Database :
OAIster
Notes :
TEXT, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1258894225
Document Type :
Electronic Resource