FNDC1 Polymorphism (rs3003174 C > T) Increased the Incidence of Coronary Artery Aneurysm in Patients with Kawasaki Disease in a Southern Chinese Population

Kun Lin,1,2,* Linyuan Zhang,1,2,* Yishuai Wang,1– 3,* Jinqing Li,1 Yufen Xu,1 Di Che,1 Hanran Mai,4 Hongyan Yu,1 Lanyan Fu,1 Bing Wei,2 Zhiyong Jiang,2 Lei Pi,1 Xiaoqiong Gu1,2 1Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China; 2Department of Blood Transfusion and Clinical Lab, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China; 3School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510006, People’s Republic of China; 4Department of Andrology, Guangzhou Women and Children’s Medical Center. Guangzhou Medical University, Guangzhou, Guangdong, 510623, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoqiong Gu; Lei Pi Email guxiaoqiong@gwcmc.org; pilei@gwcmc.orgBackground: A large number of studies demonstrated that the key to the occurrence and development of Kawasaki disease (KD) is the over-activation of immune cells and the generation of various inflammatory factors, leading to the imbalance of the immune system. Recently, mutations in the FNDC1 gene have been shown to be associated with inflammatory responses. However, there have been no reports on the relationship between FNDC1 gene and KD so far.Methods: We enrolled 1611 controls and 1459 patients with KD, including 372 patients with coronary artery aneurysm (CAA) and 179 patients with coronary artery lesion (CAL). The relationship between FNDC1 rs3003174 polymorphism and KD with CAA or without CAA was investigated.Results: This study showed no evidence that the association between FNDC1 rs3003174 C>T polymorphism and KD susceptibility was statistically significant (CT versus CC