A Comprehensive Review on Plant derived Natural products for Diabetes and its complication as nephropathy

Diabetic nephropathy is one of the most severe microangiopathies of diabetes taking heavy toll on human lives. Diabetic nephropathy is characterized by the accumulation of extracelluar matrix protein leading to irreversible decline in renal function and end stage renal disease. Incomplete knowledge about molecular mechanism underlying nephropathy limit the use of modern medicines to treat this clinical entity. Moreover, current standard of therapy for diabetic nephropathy mainly focus on reduction in hyperglycemia and hypertension. These therapies have limited effect on delaying nephropathy progression. A pressing need for novel therapies initiated studies targeting various molecular pathways involved in nephropathic changes. Herbal medicines with beneficial phytochemicals are reported to delay the progression of nephropathic changes in diabetes in various experimental studies. This review try to summarize various phytoconstituents proved to be effective in management of diabetic nephropathy. The goal is to identify promising phytoconstituents that can be translated into beneficial therapeutic options. Keywords: Diabetic complications, Medicinal plants, Phytoconstituents, Oxidative stress.