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Systems analysis and controlled malaria infection in Europeans and Africans elucidate naturally acquired immunity
- Source :
- Nature Immunology; 654; 665; 1529-2908; 5; 22; ~Nature Immunology~654~665~~~1529-2908~5~22~~
- Publication Year :
- 2021
-
Abstract
- Item does not contain fulltext<br />Controlled human infections provide opportunities to study the interaction between the immune system and malaria parasites, which is essential for vaccine development. Here, we compared immune signatures of malaria-naive Europeans and of Africans with lifelong malaria exposure using mass cytometry, RNA sequencing and data integration, before and 5 and 11 days after venous inoculation with Plasmodium falciparum sporozoites. We observed differences in immune cell populations, antigen-specific responses and gene expression profiles between Europeans and Africans and among Africans with differing degrees of immunity. Before inoculation, an activated/differentiated state of both innate and adaptive cells, including elevated CD161(+)CD4(+) T cells and interferon-γ production, predicted Africans capable of controlling parasitemia. After inoculation, the rapidity of the transcriptional response and clusters of CD4(+) T cells, plasmacytoid dendritic cells and innate T cells were among the features distinguishing Africans capable of controlling parasitemia from susceptible individuals. These findings can guide the development of a vaccine effective in malaria-endemic regions.
Details
- Database :
- OAIster
- Journal :
- Nature Immunology; 654; 665; 1529-2908; 5; 22; ~Nature Immunology~654~665~~~1529-2908~5~22~~
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1280202272
- Document Type :
- Electronic Resource