Albumin-encapsulated Nanoparticles of Naproxen Platinum(IV) Complexes with Inflammation Inhibitory Competence Displaying Effective Antitumor Activities in vitro and in vivo

Linming Li,1,* Yan Chen,1,* Qingpeng Wang,1 Zuojie Li,1 Zhifang Liu,1 Xuewen Hua,1 Jun Han,1 Chunxiao Chang,2 Zhengping Wang,1,3 Dacheng Li1,4 1Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng, 252059, People’s Republic of China; 2Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250022, People’s Republic of China; 3Liaocheng High-Tech Biotechnology Co., Ltd, Liaocheng, 252059, People’s Republic of China; 4Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, Liaocheng University, Liaocheng, 252059, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qingpeng WangInstitute of Biopharmaceutical Research, Liaocheng University, Liaocheng, 252059, People’s Republic of ChinaTel/Fax +86 635 8239773Email lywqp@126.comChunxiao ChangShandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250022, People’s Republic of ChinaEmail changcx-111@163.comBackground: Platinum(IV) complexes with inflammation inhibitory properties are much favored in improving antitumor activities. Nanodrug-delivery system as a preferable measure for antitumor therapy are widely explored in platinum(IV) drug delivery.Purpose: The aim for this study was to develop novel bovine serum albumin (BSA) nanoparticles (NPs) based on naproxen platinum(IV) complexes to display a synergistic antitumor mechanism targeting cyclooxygenase-2 (COX-2), metalloproteinase-9 (MMP-9) and inducible nitric oxide synthase (iNOS).Methods: Herein, we reported the preparation of two BSA NPs of naproxen platinum(IV) complexes, and their antitumor activities were investigated in vitro and in vivo.Results: Both NPs possessed relatively uniform size and good stability for 30 days in aqueous solution. They exhibited prominent antitumor activities in vitro, and showed g