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Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree

Authors :
Bjørnholm, Katrine Dahl
Ougaard, Maria Elm
Skovsted, Gry Freja
Knudsen, Lotte Bjerre
Pyke, Charles
Bjørnholm, Katrine Dahl
Ougaard, Maria Elm
Skovsted, Gry Freja
Knudsen, Lotte Bjerre
Pyke, Charles
Source :
Bjørnholm , K D , Ougaard , M E , Skovsted , G F , Knudsen , L B & Pyke , C 2021 , ' Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree ' , Endocrinology, Diabetes and Metabolism , vol. 4 , no. 3 , e00234 .
Publication Year :
2021

Abstract

The GLP-1 receptor (GLP-1R) in the kidney is expressed exclusively in vascular smooth muscle cells in arteries and arterioles. Downstream effects of the activation of the renal vascular GLP-1R are elusive but may involve regulation of the renin-angiotensin-aldosterone system (RAAS). The expression of Ren1 in the mouse renal vasculature was investigated by in situ hybridization after a single subcutaneous dose of liraglutide, semaglutide and after repeated injections of liraglutide. Single and repeated exposure to GLP-1R agonists induced expression of Ren1 in the renal vascular smooth muscle cell compartment compared with vehicle injected controls (p <.0001) for both semaglutide and liraglutide. The present data show a robust induction of Ren1 expression in the vascular smooth muscle cells of the kidney after single and repeated GLP-1R activation and this renin recruitment may be involved in the effects of GLP-1R agonist treatment on kidney disease.

Details

Database :
OAIster
Journal :
Bjørnholm , K D , Ougaard , M E , Skovsted , G F , Knudsen , L B & Pyke , C 2021 , ' Activation of the renal GLP-1R leads to expression of Ren1 in the renal vascular tree ' , Endocrinology, Diabetes and Metabolism , vol. 4 , no. 3 , e00234 .
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1284964150
Document Type :
Electronic Resource