Functional connectivity in aging

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A large body of research shows that aging is accompanied by localized changes in brain structure and function. However, over the past decade the neuroimaging community has begun to recognize the importance of investigating the brain as a network. Brain regions don't function independently, rather they form an expansive network that allows for communication between distant areas and enables complex cognitive functioning. Hence, age-related changes in the network structure might explain changes in cognitive functioning. Characterizing this network by investigating the brain's functional connectivity has enabled new insights into brain organization. In this chapter, we will outline how the brain's functional connectivity is affected by aging and how changes in functional connectivity relate to changes in cognitive functioning. We will address how neurodegenerative pathology influences functional connectivity and how, based on these measurements, biomarkers for clinical outcome might be developed in the future.