Stressful times for women-Reply to Edinborough et al. (2021)

This work is a reply to the comment by Edinborough et al. (2021) on our recently published paper (Penezic ' et al., 2020). In our original paper we presented the results based on the tooth cementum annulation analysis that show that the Neolithic females had higher levels of physiological stress than the Mesolithic females in the Central Balkans. We proposed the hypothesis that this was caused by differences in fertility. In their comment on our paper, Edinborough et al. (2021) question: 1) the accuracy and precision of the TCA analysis as the age estimation method 2) that pregnancies leave traces in the tooth cementum 3) our interpretation of the results. In this reply we argue: 1) that the TCA is a reliable method for age estimation 2) that the reflection of pregnancies in the tooth cementum was established by independent and previously published research and 3) we clarify that our interpretation - that the increased fertility in the Neolithic period may be the cause of the observed patterns - is a hypothesis that needs to be further tested rather than the final conclusion of our original paper.