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Phytochemical Screening and Acute Toxicity Study of Cucumis metuliferus E. Mey. Ex. Naudin Fruit Extract in Cockerels

Authors :
Usman, Joy Gararawa; National Veterinary Research Institute, Vom, Plateau State, Nigeria.
Sodipo, OA; Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, Nigeria
Sandabe, UK; Department of Veterinary Physiology, Pharmacology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria.
Usman, Joy Gararawa; National Veterinary Research Institute, Vom, Plateau State, Nigeria.
Sodipo, OA; Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, Maiduguri, Borno State, Nigeria
Sandabe, UK; Department of Veterinary Physiology, Pharmacology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Borno State, Nigeria.
Source :
International Journal of Phytomedicine; Vol 6, No 2 (2014): International Journal of phytomedicine; 243-247; 0975-0185
Publication Year :
2014

Abstract

The ripe fruits of Cucumis metuliferus were collected at Vom, Jos South Local Government Area of Plateau State, cleaned, sliced, air-dried, pulverised and cold extracted with solvents of different polarities (n-hexane, chloroform, methanol and distilled water). The ground powder and the extracts obtained were phytochemically screened for their chemical composition. These revealed the presence of saponins, alkaloids, carbohydrates, flavonoids, tannins, cardiac glycosides, steroids and terpenoids. The median lethal dose (LD50) of the methanol extract was determined in chicken by oral (p.o) and intra-peritoneal (i.p) routes. An LD50 above 5000 mg/kg body weight was established for both routes, indicating that probably the fruit of C. metuliferus is not toxic.

Details

Database :
OAIster
Journal :
International Journal of Phytomedicine; Vol 6, No 2 (2014): International Journal of phytomedicine; 243-247; 0975-0185
Notes :
application/pdf, English
Publication Type :
Electronic Resource
Accession number :
edsoai.on1295848443
Document Type :
Electronic Resource