The cardiorenal syndrome: Structural and functional aspects including associations with the shrunken pore syndrome

Mild to moderate renal impairment affects 10% of the general population. Renal impairment is difficult to detect because of the lack of symptoms, but it can be estimated by calculating the estimated glomerular filtration rate (eGFR) on the basis of plasma creatinine and/or cystatin C concentrations. Chronic kidney disease (CKD) is associated with an increased risk of development of cardiovascular disease and an increase in the mortality rate. As kidney function decreases, structural and functional changes in the heart increase. Cardiovascular disease also affects renal function, leading to CKD. This pathophysiological association between the two organs is referred to as cardiorenal syndrome (CRS). Mortality and morbidity rates are increased in patients with CRS, and early detection of this syndrome can lead to a reduction in the disease burden. To more accurately stage CKD and calculate the mortality risk, the eGFR based on creatinine (eGFRCR) and cystatin C (eGFRCYS) is recommended for use in clinical practice. The eGFRCYS and eGFRCR usually correspond well with each other. In some individuals, the eGFRCYS/eGFRCR ratio is < 0.7, and it is associated with increased morbidity and mortality. A selective decrease in renal filtration of cystatin C is thought to cause the difference between eGFRCYS and eGFRCR, and this condition is called shrunken pore syndrome (SPS). This thesis presents studies on the early detection of CRS and the association of SPS with mortality and morbidity in patients with heart failure (HF) and in individuals who were randomly chosen from a population-based cohort. In Paper I, data from 1504 individuals without HF from the Malmö Prevention Project, which is a population-based cohort, showed significant associations between mild to moderate impairment of renal function and echocardiographic markers of cardiac structure and diastolic function. These findings support the hypothesis that there is an interaction between the kidney and heart, even at