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Abnormal hypothalamic-pituitary-adrenal axis function in rheumatoid arthritis: Effects of nonsteroidal antiinflammatory drugs and water immersion.
- Publication Year :
- 2012
-
Abstract
- Objective. To investigate the effects of nonsteroidal antiinflammatory drug (NSAID) therapy and water immersion on hypothalamic-pituitary-adrenal (HPA) axis function in rheumatoid arthritis (RA). Methods. Plasma levels of adrenocorticotropic hormone (ACTH) and serum and urine levels of cortisol were compared in untreated RA patients, NSAID-treated RA patients, and healthy control subjects. Results. ACTH levels were significantly higher in untreated RA patients (mean +/- SEM integrated area 11,377 +/- 5,246 hours ng/liter) than in NSAID-treated RA patients (2,285 +/- 388 hours ng/liter) or healthy controls (1,845 +/- 35.5 hours ng/liter) (P < 0.001). Serum and urine cortisol levels were not significantly different between groups. Two-hour head-out water immersion had no effect. Conclusion. Elevated ACTH levels without hypercortisolemia occur in untreated RA. NSAID therapy alters HPA axis response, but immersion has no effect.
Details
- Database :
- OAIster
- Notes :
- O'Hare J.P., Morand E.F., Medbak S., Zaman M., Perry L., Goulding N.J., Maddison P.J., Hall J.
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1305133250
- Document Type :
- Electronic Resource