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Trabectedin-Related Heart Failure: Case Report and a Systematic Review of the Literature
- Source :
- Frontiers in oncology, 11
- Publication Year :
- 2021
-
Abstract
- New drugs come not only with benefits but also with unexpected toxicities which need to be promptly recognized and managed. Starting from a scholar case of acute heart failure with preserved ejection fraction following the administration of trabectedin (ET-743, Yondelis®) in a patient with a metastatic solitary fibrous tumor, we performed a systematic review of the literature encompassing the results of previous cardiac safety analysis published ten years ago, a review of clinical trials published during the last 10 years as well as single-case descriptions related to trabectedin cardiotoxicity. The estimated incidence of cardiac toxicity was 3,4% among patients receiving trabectedin, with recent data suggesting a higher rate of heart failure than previously recognized. Previous or concomitant anthracyclines exposure may represent a risk factor. Assaying for NT-pro-BNP may be useful for the early detection of individuals with trabectedin-induced heart failure.<br />SCOPUS: re.j<br />info:eu-repo/semantics/published
Details
- Database :
- OAIster
- Journal :
- Frontiers in oncology, 11
- Notes :
- Catherine, Julien, Jungels, C., Durieux, ValeĢrie, Deliens, Coralie, Grigoriu, Bogdan
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1313393370
- Document Type :
- Electronic Resource