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Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
- Source :
- Huynh-Le , MP , Fan , CC , Karunamuni , R , Thompson , WK , Martinez , M E , Eeles , RA , Kote-Jarai , Z , Muir , K , Schleutker , J , Pashayan , N , Batra , J , Grönberg , H , Neal , DE , Donovan , JL , Hamdy , FC , Martin , RM , Nielsen , SF , Nordestgaard , BG , Wiklund , F , Tangen , C M , Giles , GG , Wolk , A , Albanes , D , Travis , RC , Blot , WJ , Zheng , W , Sanderson , M , Stanford , J L , Mucci , LA , West , CML , Kibel , AS , Cussenot , O , Berndt , SI , Koutros , S , Sørensen , KD , Cybulski , C , Grindedal , EM , Menegaux , F , Khaw , KTH , Park , JY , Ingles , SA , Maier , C , Hamilton , RJ , Thibodeau , SN , Rosenstein , B S , Lu , YJ , Watya , S , Vega , A , Kogevinas , M , Penney , KL , Huff , C , Teixeira , MR , Multigner , L , Leach , RJ , Cannon-Albright , L , Brenner , H , John , EM , Kaneva , R , Logothetis , CJ , Neuhausen , SL , De Ruyck , K , Pandha , H , Razack , A , Newcomb , LF , Fowke , JH , Gamulin , M , Usmani , N , Claessens , F , Gago-Dominguez , M , Townsend , PA , Bush , WS , Roobol - Bouts , M , Parent , MÉ , Hu , JJ , Mills , IG , Andreassen , OA , Dale , AM & Seibert , TM 2021 , ' Polygenic hazard score is associated with prostate cancer in multi-ethnic populations ' , Nature Communications , vol. 12 , no. 1 , 1236 .
- Publication Year :
- 2021
-
Abstract
- Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS1) is associated with age at prostate cancer diagnosis and improves screening accuracy in Europeans. Here, we evaluate performance of PHS2 (PHS1, adapted for OncoArray) in a multi-ethnic dataset of 80,491 men (49,916 cases, 30,575 controls). PHS2 is associated with age at diagnosis of any and aggressive (Gleason score ≥ 7, stage T3-T4, PSA ≥ 10 ng/mL, or nodal/distant metastasis) cancer and prostate-cancer-specific death. Associations with cancer are significant within European (n = 71,856), Asian (n = 2,382), and African (n = 6,253) genetic ancestries (p < 10−180). Comparing the 80th/20th PHS2 percentiles, hazard ratios for prostate cancer, aggressive cancer, and prostate-cancer-specific death are 5.32, 5.88, and 5.68, respectively. Within European, Asian, and African ancestries, hazard ratios for prostate cancer are: 5.54, 4.49, and 2.54, respectively. PHS2 risk-stratifies men for any, aggressive, and fatal prostate cancer in a multi-ethnic dataset.
Details
- Database :
- OAIster
- Journal :
- Huynh-Le , MP , Fan , CC , Karunamuni , R , Thompson , WK , Martinez , M E , Eeles , RA , Kote-Jarai , Z , Muir , K , Schleutker , J , Pashayan , N , Batra , J , Grönberg , H , Neal , DE , Donovan , JL , Hamdy , FC , Martin , RM , Nielsen , SF , Nordestgaard , BG , Wiklund , F , Tangen , C M , Giles , GG , Wolk , A , Albanes , D , Travis , RC , Blot , WJ , Zheng , W , Sanderson , M , Stanford , J L , Mucci , LA , West , CML , Kibel , AS , Cussenot , O , Berndt , SI , Koutros , S , Sørensen , KD , Cybulski , C , Grindedal , EM , Menegaux , F , Khaw , KTH , Park , JY , Ingles , SA , Maier , C , Hamilton , RJ , Thibodeau , SN , Rosenstein , B S , Lu , YJ , Watya , S , Vega , A , Kogevinas , M , Penney , KL , Huff , C , Teixeira , MR , Multigner , L , Leach , RJ , Cannon-Albright , L , Brenner , H , John , EM , Kaneva , R , Logothetis , CJ , Neuhausen , SL , De Ruyck , K , Pandha , H , Razack , A , Newcomb , LF , Fowke , JH , Gamulin , M , Usmani , N , Claessens , F , Gago-Dominguez , M , Townsend , PA , Bush , WS , Roobol - Bouts , M , Parent , MÉ , Hu , JJ , Mills , IG , Andreassen , OA , Dale , AM & Seibert , TM 2021 , ' Polygenic hazard score is associated with prostate cancer in multi-ethnic populations ' , Nature Communications , vol. 12 , no. 1 , 1236 .
- Notes :
- application/pdf, English
- Publication Type :
- Electronic Resource
- Accession number :
- edsoai.on1313631518
- Document Type :
- Electronic Resource